Clinical course of RSV infection in adult BALB/c mice
Mice infected with RSV-RFP experienced greatest weight loss at 5 dpi
(2.3±0.7%, p <0.05), returning to baseline at 7 dpi,
followed by a significantly increased weight gain at 21 dpi compared to
day 0 baseline weights (5.4±1.5% p <0.01) (Figure 1A).
Clinical symptoms (clinical score) were evident at 3 dpi, peaking at 7
dpi and returning to baseline at 21 dpi (Figure 1B). Viral titres, as
determined in lung tissue using qPCR, were significantly elevated at 3
dpi, peaking at 5 dpi and declining by 7 dpi, returning to undetectable
levels by 21 dpi (Figure 1C).