Lung tissue leukocyte subtype responses following RSV-RFP
infection
A significant increase in the percentage of lung tissue conventional
dendritic cells (cDC) was noted on 7 and 21 dpi (Figure 3A), with lung
tissue macrophages also significantly increased at 21 dpi (Figure 3B).
Lung B cells numbers were significantly increased at 7 dpi. They
remained elevated at 21 dpi although though this was not statistically
significant (Fig. 3C). No increase in plasmacytoid DC (pDC) or
granulocytes numbers were observed in lung tissue at any time point
following infection (Figures 3D and 3E). Thus, lung tissue antigen
presenting cell (APC) subsets showed the dominant response to RSV in
lung tissue at 7 dpi, with cDC and macrophages remaining significantly
elevated above baseline at 21 dpi.