TC Downregulates the Expression related of Rho/ROCK signal
pathway Proteins in AMDC
To further explore the effect of TC may on the Rho/ROCK signal pathway
of AMDC, the expression of several proteins which were crucial for Rho
(RhoA, RhoB, RhoC) and ROCK (ROCK1, ROCK2) was detected after treatment
with different concentrations of TC (0, 6, 12 μg/mL) for 48 h. As shown
in Figure 8 , Western blot analysis
showed that TC dose-dependently decreased the expression of RhoA, RhoB,
RhoC, ROCK1, ROCK2 in AMDC. All of these proteins decreased and in
dose-dependent manner.