2.4 Statistical analysis
Geometric means and 95% confidence intervals (CIs) of PK parameter P/O
ratios were calculated using the DescTools package (v0.99.44, Signorellet mult. al. ) for R. Normal distribution of P/O ratios was
examined through the Shapiro-Wilk test. The predictive performance of
the PBPK model was deemed adequate if the geometric means of PK
parameter P/O ratios fell between 0.8-fold and 1.25-fold (1.25-fold
prediction error range). In addition to assessing whether geometric mean
PK parameter P/O ratio fell within the relatively narrow 1.25-fold
prediction error range, the proportion of all PK parameter P/O ratios
falling within the wider 2-fold prediction error range was determined.
Results