Introduction
In younger patients Lamin heart disease is an underdiagnosed etiology of
complex irregular atrial arrhythmias occurring in the absence of
pulmonary vein activity. As these arrhythmias can be impossible to map
by serial contact mapping, we describe the use of a novel noncontact
mapping array to characterize the septal origin of these atrial
flutters, close to the site of conduction system disease in two sisters
with Lamin A/C mutation. In addition, very unusual morphological
abnormalities such as ventricular noncompaction and abnormal pulmonary
vein connection are reported for the first time in Lamin heart disease.