AUTHOR CONTRIBUTIONS
M.F.S.S. and M.H.G.F. conceived the work, contributed to the design of the study and the writing of the manuscript. M.F.S.S, A.C.M.D.P., F.C.E.O, F.M.C.A and L.F.C. were responsible for the recruitment, follow up, data collection, laboratory analysis and data processing work. M.F.S.S made the graphs and figures.  F.M.C.A supervised the project. All authors involved in writing, review and editing, approved the final manuscript version.