Conclusion
According to our findings, prophylactic use of caffeine is beneficial
compared to caffeine therapy in reducing the incidence of AOP, duration
of mechanical ventilator and oxygen therapy, BPD, PDA and ROP. It is
well appreciated that prophylactic caffeine without increasing the risk
of NEC, IVH and death before discharge. Thus, we support on caffeine
advocate prophylactic use in several publicly available national and
international guidelines. Furthermore, future research is needed to
investigate the optimal caffeine prophylaxis dosing and plan for
long-term follow-up neonatal outcomes.