Patient characteristics
A total of 72 patients were diagnosed with NECC in our department
between 2009 and 2022. Eleven patients not subjected to surgery and two
patients without detailed follow-up data were excluded. The remaining 58
patients were considered eligible for our study. We divided patients
into two groups based on their histological subtypes. The pure group
demonstrated only one histological subtype, while the mixed group showed
two or more histological subtypes. A schematic diagram of patients is
shown in Figure.1.
A total of 31 patients (53.4%) were included in the pure group, and 27
patients (46.6%) were included in the mixed group. In the mixed group,
squamous cell carcinoma (SCC) and adenocarcinoma (AC) were the most
common types. Furthermore, in this group, seven patients showed three
different histological types. The pathological results are shown in
figure 2.
The clinicopathological characteristics of all patients are shown in
Table 1. The median follow-up period was 39.5 months (range, 8.4–70.6).
A total of 44 patients (75.9%) and 14 patients (24.1%) showed tumor
sizes of ≤4 cm and>4 cm, respectively. Among them, 5 (8.6%), 37
(63.8%), 13 (22.4%), and 3 (5.2%) patients did not receive adjuvant
therapy, received both chemotherapy and radiotherapy, received only
chemotherapy, and received only radiotherapy, respectively. A total of
33 (56.9%), 18 (31.0%), and 7 (12.1%) patients underwent laparoscopic
surgery, robotic surgery, and open surgery, respectively. The
postoperative pathological results showed that lymph node metastasis was
present in 17 patients. Furthermore, 6, 27, 7, and 4 patients showed
uterus invasion, lymph-vascular space invasion (LVSI), perineural
invasion, and parametrium invasion, respectively. Meanwhile, 2 patients
showed positive surgical margins, and 46 patients showed more than 1/3
of deep stromal invasion.