Treatment outcome and survival analysis
As shown by the follow-up survey, 23 patients (39.7%) reported tumor recurrence with distant metastasis, and 18 of them died. The median OS was 32.5 months (range, 4.1–60.9). Metastasis to multiple sites was most commonly observed in eight patients with distant metastasis. Other metastasis sites included the lungs (n=5), bone marrow (n=4), livers (n=4), distant lymph nodes (n=1), and brain (n=1). In addition, the distant metastasis was significantly associated with OS (p <0.0001).The metastasis sites and KM analysis are showed in figure 3.
A total of 40 patients (69.0%) survived during a median follow-up duration of 39.5 months. The Kaplan-Meier survival analysis was used to verify the factors influencing the OS. Mixed pathology (p =0.044), uterus invasion (p <0.0001), surgical margin (p =0.035) and parametrium invasion (p =0.025) were associated with the OS (Figure 4). Meanwhile, the LVSI、depth of stromal invasion, and lymph node metastasis did not show significant relevance with respect to the OS.