Physical stability
Table 3 expose the results of the physical stability parameters for the four formulations. The ointment formulation obtained a level 1 score in extensibility property, due to its high petrolatum content, similar to the classical formulation. It should be noted that the emulsion formulation resulted in a pre-separation of phases at t=14 days and a definitive breakdown of the emulsion at t=21 days, therefore it was assigned a level 1 score in absence of phase separations property. The Score of level 1 in the absence of crystals property for the gel formulation, was awarded by the presence of white particles. The mean particle size of prepared liposomes determined a good quality result of the analysis with a polidispersity index value <0.2, indicating a homogenous dispersion. The EE% turned out to be very favorable for the liposomal formulation, with a high load of rapamycin per liposome formed.