Physical stability
Table 3 expose the results of the physical stability parameters for the
four formulations. The ointment formulation obtained a level 1 score in
extensibility property, due to its high petrolatum content, similar to
the classical formulation. It should be noted that the emulsion
formulation resulted in a
pre-separation of
phases at t=14 days and a definitive breakdown of the emulsion at t=21
days, therefore it was assigned a level 1 score in absence of phase
separations property. The Score of level 1 in the absence of crystals
property for the gel formulation, was awarded by the presence of white
particles. The mean particle size of prepared liposomes determined a
good quality result of the analysis with a polidispersity index value
<0.2, indicating a homogenous dispersion. The EE% turned out
to be very favorable for the liposomal formulation, with a high load of
rapamycin per liposome formed.