Factors
Pelvic pain since commencing testosterone (N=351) N (%) No pelvic pain since commencing testosterone (N=122) N (%)
Odds ratio (95% CI)*
P-value*
Persistent menstruation Yes No Unsure/Prefer not to say 53 (16%) 266 (80%) 13 (4%) 12 (11%) 94 (86%) 3 (3%)
4.46 (1.33, 14.97)
0.015
Genital dryness Sometimes/Always Never Unsure/Prefer not to say 192 (55%) 140 (40%) 19 (5%) 50 (41%) 65 (54%) 6 (5%)
1.82 (0.89, 3.74)
0.103
Intrauterine device in situ Yes No Unsure/Prefer not to say 38 (11%) 312 (89%) 1 (0.3%) 9 (7%) 112 (93%) 0
1.74 (0.37, 8.11)
0.480
Duration of testosterone therapy (months) Median (IQR)
34 (17, 61)
24 (10, 57)
1.00 (1.00, 1.01)
0.524
Diagnosis of endometriosis Yes No Unsure/Prefer not to say 39 (11%) 302 (86%) 9 (3%) 3 (3%) 117 (97%) 1 (0.8%)
4.41 (0.41, 47.54)
0.221
Diagnosis of vulvodynia or vaginismus Yes No 67 (19%) 284 (81%) 8 (7%) 114 (93%)
1.95 (0.66, 5.78)
0.230
Previous pregnancy None One or more Unsure/Prefer not to say 311 (89%) 39 (11%) 1 (0.3%) 109 (90%) 12 (10%) 0 (0.0)
1.17 (0.31, 4.45)
0.821
Current or previous PTSD Current/previous Never Unsure/Prefer not to say 122 (35%) 194 (56%) 32 (9%) 17 (14%) 92 (76%) 12 (10%)
2.50 (1.07, 5.85)
0.035
Current or previous depression Current/previous Never Unsure/Prefer not to say 292 (83%) 50 (14%) 9 (3%) 82 (67%) 34 (28%) 6 (5%)
2.62 (0.86, 7.98)
0.091
Current or previous anxiety Current/previous Never Unsure/Prefer not to say 280 (80%) 59 (17%) 11 (3%) 78 (65%) 35 (29%) 7 (6%)
0.97 (0.32, 2.95)
0.961
Obesity Body mass index <30 kg/m2 Body mass index ≥30 kg/m2 232 (67%) 116 (33%) 96 (80%) 24 (20%)
1.38 (0.62, 3.07)
0.425
Pain with orgasm Sometimes/Always Never Unsure/Prefer not to say 208 (59.3) 125 (36.1) 13 (3.8) 10 (8.6) 99 (85.3) 7 (6.0)
32.72 (10.65, 100.52)
<0.0001
Pain with touching of external genitalia Sometimes/Always Never Unsure/Prefer not to say 127 (36.2) 212 (61.6) 5 (1.5) 23 (19.8) 93 (80.2) 0 (0.0)
0.84 (0.32, 2.16)
0.715
Pain with penetrative sexual activities Sometime/Always Never Unsure/Prefer not to say Don’t do penetrative activities 230 (66.5) 60 (17.3) 9 (2.6) 47 (13.6) 50 (43.1) 29 (25.0) 2 (1.7) 35 (30.2)
1.18 (0.58, 2.40)
0.640