Calcific Aortic valve disease:
Valvular diseases of heart are another major concern in all parts of the
world which means both the developing and developed world. The
etiologies might vary but still they possess a major health related
issue. P2Y2 receptors are known to play an important role in this. They
are required for the normal survival of valvular tissue [18]. A high
level of membrane-bound ecto-nucleotidase pyrophosphatase 1 present in
the calcific aortic valve is responsible for the further progression of
the disease. Treating the rats that are given warfarin with ARL67156 is
found be effective in preventing the development of calcification of
aortic valve. This is a commercially available nucleotide analog and
CD39 inhibitor [19]. These studies suggest that the purinergic
receptors or the nucleotides could be exploited for development of
future therapeutics that could help in arresting the progress of
calcification of aortic valve. This will be a great achievement in the
field of therapeutics as only surgical and minimally invasive techniques
are the mainstay in treatment with conflicting results.