Introduction:
Platelets are vital cells in our body homeostasis they play an important role in homeostasis which is well known. The coagulation or thrombotic effect caused by platelets is mainly mediated by platelet purinergic receptors namely P2Y1, P2Y12 and P2X1. P2Y1 and P2Y12 are G-protein coupled receptors but P2X1 is an adenosine gated nonselective cation channel [1]. P2Y12 activation causes platelet adenyl cyclase inhibition but in combination with P2Y1 it causes platelet aggregation [2]. Stimulation of P2X1 causes conformational changes in platelets and synergize the action mediated by former two receptors [3]. The role of these receptors in various other conditions have been identified. They are also identified in various other systems other than platelets. Their role apart from thrombotic and platelet related disorders are slowly getting broadened and they are being recognized as candidates in various disorders. So, the knowledge regarding their role in non-thrombotic diseases has to be given special emphasis and this could pave the way for sustained research in this area. This in turn can produce important discoveries that could ultimately serve as newer modalities in areas of diagnostics, drug discovery and therapeutics.