Calcific Aortic valve disease:
Valvular diseases of heart are another major concern in all parts of the world which means both the developing and developed world. The etiologies might vary but still they possess a major health related issue. P2Y2 receptors are known to play an important role in this. They are required for the normal survival of valvular tissue [18]. A high level of membrane-bound ecto-nucleotidase pyrophosphatase 1 present in the calcific aortic valve is responsible for the further progression of the disease. Treating the rats that are given warfarin with ARL67156 is found be effective in preventing the development of calcification of aortic valve. This is a commercially available nucleotide analog and CD39 inhibitor [19]. These studies suggest that the purinergic receptors or the nucleotides could be exploited for development of future therapeutics that could help in arresting the progress of calcification of aortic valve. This will be a great achievement in the field of therapeutics as only surgical and minimally invasive techniques are the mainstay in treatment with conflicting results.