Introduction:
Platelets are vital cells in our body homeostasis they play an important
role in homeostasis which is well known. The coagulation or thrombotic
effect caused by platelets is mainly mediated by platelet purinergic
receptors namely P2Y1, P2Y12 and P2X1. P2Y1 and P2Y12 are G-protein
coupled receptors but P2X1 is an adenosine gated nonselective cation
channel [1]. P2Y12 activation causes platelet adenyl cyclase
inhibition but in combination with P2Y1 it causes platelet aggregation
[2]. Stimulation of P2X1 causes conformational changes in platelets
and synergize the action mediated by former two receptors [3]. The
role of these receptors in various other conditions have been
identified. They are also identified in various other systems other than
platelets. Their role apart from thrombotic and platelet related
disorders are slowly getting broadened and they are being recognized as
candidates in various disorders. So, the knowledge regarding their role
in non-thrombotic diseases has to be given special emphasis and this
could pave the way for sustained research in this area. This in turn can
produce important discoveries that could ultimately serve as newer
modalities in areas of diagnostics, drug discovery and therapeutics.