BMI and BMI Percentile Change by Genotype
In the adult patient group, 35 adults were identified as having the homozygous F508del genotype, while the other 33 were heterozygous F508del genotype. In the homozygous genotype group, the mean positive change in BMI was 1.46 (1.52) kg/m2, while the average change in the heterozygous group was a gain of 1.49 (1.77) kg/m2. In the pediatric group, there were 27 children with the homozygous genotype; they had a mean increase in BMI percentile of 9.04 (15.83). Eleven children had an F508del heterozygous genotype; they had an average increase in BMI percentile 6.63 (20.26) percentile.