Methods
In the present study we enrolled children with persistent moderate to
severe asthma who attended at Clínica Las Condes, Santiago and had
pulmonary function tests: oscillometry followed by spirometry performed
with a Vyaire Vyntus model v‐176430 spirometer-oscillometer and
according to ATS/ERS guidelines (3, 4). A systematic medical history on
birth weight, gestational age, history of of maternal asthma, and pre
and post-natal maternal smoking was obtained. The differences between
groups were calculated with the ANOVA test and the post hoc analysis
with the Tukey test. The study was approved by the Ethics Committee of
the institution; and informed consent was applied to the
parents/guardians, and assent to the patients.