iii.Abstract and keywords
Aim: The aim of the present study was to explore the tolerance
march in children and establish probable factors that affect the
prognosis of an egg allergy (EA).
Methods: Two hundred children 6 months to 2.5 years old with
atopic dermatitis (AD) were recruited into our study from 2018 to 2019.
EA was diagnosed based on medical history, the skin prick test (SPT),
and the oral food challenge test
(OFC) ,EA was diagnosed in 78,among
those, 7 were allergic only to egg yolk (OnlyEYA), 20 to egg white
(OnlyEWA), and 51 to whole egg (WEA). Logistic regression analysis was
used to detect the disease course and related risk factors of outcomes.
The receiver operating characteristic curve was used to establish a
predicting model.
Results: The Scoring
Atopic Dermatitis score in the WEA group was more severe and persistent
than that in the other groups. Forty-three cases of EA developed
clinical tolerance (average age, 32.3 ± 8.7 months). The tolerance rate
of EYA was 75.9% and EWA was 56.3%. The SPT wheal diameter at initial
diagnosis (SPTdiag) was the risk factor for persistent
EA. The SPT wheal diameter after 6 months
(△SPT6mo) in the
tolerant group decreased markedly compared to that in the persistent EA
group. Tolerance was higher when △EW-SPT6mo ≥ 39.5% or
△EY-SPT6mo ≥ 27%.
Conclusion: The initial SPTdiag and
SPT6mo values were significantly correlated with and can
predict outcomes of EA.
Key words: Egg allergy,
atopic dermatitis, outcome, related factors.