Primary Exposure and Outcomes:
The primary exposure was AVDSf at PARDS onset analyzed as a continuous
variable. The primary outcome was RV systolic dysfunction as defined by
abnormal RV GLS (dichotomous as defined above). Secondary outcomes
included echocardiogram evidence of pulmonary hypertension and RV
systolic dysfunction as defined by RV strain, TAPSE z-score, FAC, and
qualitative assessments as well as measures of oxygenation including
oxygenation index (OI = mPaw x FIO2 x 100 /
PaO2) and PaO2/FiO2ratio.