Strengths and Limitations
This review focused on vaccinated children and adolescents and provided a comprehensive review and synthesis of the evidence on the BioNTech-Pfizer vaccine’s symptoms among children and adolescents. There are several limitations to this systematic review. To begin with, the included studies had low to intermediate methodological quality in terms of their sampling method, measurement validity, and statistical analysis. These points must be considered while evaluating the results. Secondly, we omitted a few studies from our analyses due to the lack of and/or ambiguous information. These studies reported outcomes of the vaccine, however, did not differentiate between adult and pediatric populations and the results could not be extrapolated. Nonetheless, despite these limitations, this is the first review looking at the pediatric population exclusively. Furthermore, the search and inclusion are a representation of the current published literature and should be considered the most recent and up-to-date evidence collectedly found.