Strengths and Limitations
This review focused on vaccinated
children and adolescents and provided a comprehensive review and
synthesis of the evidence on the BioNTech-Pfizer vaccine’s symptoms
among children and adolescents. There are several limitations to this
systematic review. To begin with, the included studies had low to
intermediate methodological quality in terms of their sampling method,
measurement validity, and statistical analysis. These points must be
considered while evaluating the results. Secondly, we omitted a few
studies from our analyses due to the lack of and/or ambiguous
information. These studies reported outcomes of the vaccine, however,
did not differentiate between adult and pediatric populations and the
results could not be extrapolated. Nonetheless, despite these
limitations, this is the first review looking at the pediatric
population exclusively. Furthermore, the search and inclusion are a
representation of the current published literature and should be
considered the most recent and up-to-date evidence collectedly found.