Study Characteristics and Cumulative Analysis
In total, 6 reports were included in this study (23-28). There were no randomized trials, and all studies were observational (retrospective case series, and case report) as shown in Table 2. A total of 78 vaccinated children and adolescents were included. Gender was provided for all patients and included 55 males and 23 females. The mean age was 15.6, ranging between 14.5 to 18 years old. A total of 66 out of 78 patients were found to be White and the dominant race in the analysis. One median was provided by one study and was not calculated in the analysis. BMI was included in only two studies.
The clinical symptoms of the BioNTech-Pfizer vaccine on vaccinated children and adolescents are demonstrated in Table 3. The symptoms of vaccinated children and adolescents were listed and summarized. The most common clinical symptoms were found in chest pain (35%), fever (32%), myalgia/muscle pain (17%), headache (8%)  , fatigue (13%), SOB (17%), vomiting (5%), nausea (4%), malaise (4%) and local pain (3%).
Table 2 . Summary of relevant research studies and characteristics of vaccinated children and adolescents after BioNTech-Pfizer COVID-19 vaccine