Abstract:
Background: The BioNTech-Pfizer vaccine is the only vaccine offered to
children among all available vaccines. However, limited evidence is
available about the clinical outcomes of COVID-19 vaccines, especially
among children and adolescents. This review offers a comprehensive and
up-to-date overview of the BioNTech-Pfizer vaccine’s current information
on children and adolescents.
Methods: The review was conducted following the PRISMA guidelines; a
comprehensive search was performed in PubMed, Scopus, MEDLINE, and
EMBASE databases for research publications COVID-19 published between
December 2019 and October 2021. All studies reporting on the outcomes of
vaccinating children in their respective institutes were included.
Results: A total of 78 vaccinated children and adolescents from 6
studies were included. The majority of symptomatic vaccinated pediatrics
were males (71%). The mean age was 15.6 years, and the BMI was 24.1.
The most common clinical symptoms were found in chest pain (35%), fever
(32%), and myalgia (17%). The most common cardiac symptom in the EKG
results was ST elevation, and 35% of vaccinated pediatrics had elevated
serum troponin. The hospitalization, including ICU admission, was lower
than in unvaccinated groups. Statistically significant associations (P =
<0.05) were found in two symptoms (fever and headache) between
the vaccinated and non-vaccinated pediatric groups.
Conclusions: Although we found better outcomes in the vaccinated group
versus the non-vaccinated pediatric group, more studies are still
crucial to further understand the specific etiology underlying
post-vaccination, particularly myocarditis, psychological impact, and
other cardiac clinical symptoms in children and adolescents after
receiving the BioNTech-Pfizer vaccine.
Abbreviations :
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
World Health Organization (WHO)
The Preferred Reporting Items for Systematic Reviews (PRISMA)
Middle East respiratory syndrome coronavirus (MERS-CoV)
Ribonucleic acid (RNA)
Messenger RNA (mRNA)
Deoxyribonucleic acid (DNA)
Food and Drug Administration (FDA)
Intensive care unit (ICU)
United States of America (USA)
Body mass index (BMI)
Electrocardiogram (ECG or EKG)
Congenital Valvular Disease (CVD)
Magnetic resonance imaging (MRI)
Late Gadolinium Enhancement (LGE)
Morbidity and Mortality Weekly Report (MMWR)
Conflict of Interest: All authors declare there is no conflict
of interest.
Funding: None
Acknowledgment: The publication of this article was funded by Qatar
National Library.