Conclusion
Despite the rarity of this disease and the presence of different treatment modalities for LBL, a few general conclusions can be made including: the modern therapy of LBL should follow the same principles of ALL therapy; taking into account the scarce results of salvage therapy and the optimal results obtained with frontline therapy of pediatric patients a comparable therapeutic approach should be adopted in all patients regardless of age; a regimen including 5 g/m2 MTX blocks could be part of a highly effective modality, in which MRT could be safely omitted and low-dose cranial irradiation should be delivered only to patients with advanced forms of the disease. Furthermore, seeking for stronger prognostic indicators, the presence of adverse (onco)-genetic abnormalities and the early evaluation of CT/PET and MDD/MRD in the future could allow a more rational, risk oriented use of MRT, SCT, and new-targeted therapies [2].
Conflict of Interest: The authors declare no conflict of interest.
Funding: No funding was received for this article.
Author Contributions: F.M was responsible for data collection and revision of the manuscript. A.SM was responsible for preparation of early draft of the manuscript. R.D was responsible for final composition and revision of the manuscript. All authors contributed equally to the manuscript.
Consent: A written consent form was obtained from the patient for participation in this study and sharing their clinical history in this article.
Ethical approval: This study was performed according to the principles outlined by the World Medical Association’s Declaration of Helsinki on experimentation involving human subjects. This study has been further approved by the ethics committee of Mazandaran University of Medical Sciences.
Acknowledgments: None