Conclusion
Despite the rarity of this disease and the presence of different
treatment modalities for LBL, a few general conclusions can be made
including: the modern therapy of LBL should follow the same principles
of ALL therapy; taking into account the scarce results of salvage
therapy and the optimal results obtained with frontline therapy of
pediatric patients a comparable therapeutic approach should be adopted
in all patients regardless of age; a regimen including 5 g/m2 MTX blocks
could be part of a highly effective modality, in which MRT could be
safely omitted and low-dose cranial irradiation should be delivered only
to patients with advanced forms of the disease. Furthermore, seeking for
stronger prognostic indicators, the presence of adverse (onco)-genetic
abnormalities and the early evaluation of CT/PET and MDD/MRD in the
future could allow a more rational, risk oriented use of MRT, SCT, and
new-targeted therapies [2].
Conflict of Interest: The authors declare no conflict of
interest.
Funding: No funding was received for this article.
Author Contributions: F.M was responsible for data collection
and revision of the manuscript. A.SM was responsible for preparation of
early draft of the manuscript. R.D was responsible for final composition
and revision of the manuscript. All authors contributed equally to the
manuscript.
Consent: A written consent form was obtained from the patient
for participation in this study and sharing their clinical history in
this article.
Ethical approval: This study was performed according to the
principles outlined by the World Medical Association’s Declaration of
Helsinki on experimentation involving human subjects. This study has
been further approved by the ethics committee of Mazandaran University
of Medical Sciences.
Acknowledgments: None