INTRODUCTION
Leukemia is a potentially fatal and life-threatening neoplasm affecting the hematopoietic system.1 Direct invasion of leukemic neoplastic cells in the skin layers is named leukemia cutis.1 Leukemia cutis is seen in various frequencies in leukemia subtypes, but it is most commonly seen in acute myelomonocytic leukemia (AML-4) and AML-M5 which have the highest rates of skin manifestations.2 Approximately, about 2.9%–3.7% of AML cases present with leukemia cutis.2
We report a case of a 76-year-old man with skin rash who was diagnosed later with acute myeloid leukemia (AML). The patient presented with hyperpigmented patches on the face and upper trunk with ocular and oral mucosal changes upon examination. Further workup revealed patient having acute myeloid leukemia (AML-M5) and skin biopsy showed infiltration with myeloblasts.