The WisDM Green second order quadratic series was derived from stepwise regression that performed bidirectional elimination of the estimated coefficients using the P values from F-statistics in MATLAB 2020b (Mathworks, Inc.). This quadratic series was then used to derive the predicted %Yield data for all possible combinations consisting of 8 compounds in 3 concentration levels (38 = 6,561). Box-Cox transformation was explored to determine appropriate transformations to the %Yield output data. Residual-based outlier analysis was performed based on the residual distribution of the %Yield data.