This work was based on prospective optimization and validation with the selected 8 compounds. Though the top WisDM Green-pinpointed combinations were able to achieve 15 – 35% increase in %Yield, further studies with an expanded list of compounds may add additional insight into even further improving yield. Importantly, the optimal compound combinations may not have any effect, or sub-optimal outcome, in other species of plants or different experimental conditions. A proof-of-concept study with a single validation model to design compound combinations is unlikely to broadly enhance yield across multiple types of plants. However, subsequent studies to optimize compound combinations in multiple species of plants may enable the discovery of a universal compound combination. Nonetheless, this work provided insight into the role of properly combining compounds at the correctly pinpointed respective concentrations during the process of optimal yield enhancement in agricultural applications.