Weight gain:
Grade 1-2
Grade 3
|
35 (60.3)
25 (43.1)
10 (17.2)
|
7 (11.7)
5 (8.3)
2 (3.3)
|
33 (61.1)
24 (44.4)
9 (16.7)
|
<0.001
|
<0.001
|
0.934
|
<0.001
|
Increased nocturnal urine: Grade 1-2 |
29 (50.0) |
13 (21.7) |
30 (55.6) |
<0.001 |
0.001 |
0.556 |
<0.001 |
Night sweats: Grade 1-2 |
23 (39.7) |
9 (15.0) |
22 (40.7) |
0.003 |
0.003 |
0.907 |
0.002 |
Insomnia: Grade 1-2 |
21 (36.2) |
8 (13.3) |
18 (33.3) |
0.010 |
0.004 |
0.750 |
0.011 |
Libido decreased: Grade 1-2 |
21 (36.2) |
15 (25.0) |
23 (42.6) |
0.132 |
0.186 |
0.489 |
0.047 |
Breast pain: Grade 1-2 |
19 (32.8) |
12 (20.0) |
13 (24.1) |
0.270 |
0.115 |
0.309 |
0.600 |
Fatigue: Grade 1-2 |
18 (31.0) |
14 (23.3) |
22 (40.7) |
0.135 |
0.347 |
0.284 |
0.046 |
Edema face: Grade 1-2 |
14 (24.1) |
3 (5.0) |
14 (25.9) |
0.005 |
0.003 |
0.827 |
0.002 |
Vaginal dryness:
Grade 1-2
Grade 3
|
13 (22.4)
12 (20.7)
1 (1.7)
|
9 (15.0)
9 (15.0)
0 (0.0)
|
16 (29.6)
16 (29.6)
0 (0.0)
|
0.170
|
0.301
|
0.384
|
0.059
|
Abdominal distension: Grade 1-2 |
12 (20.7) |
10 (16.7) |
17 (31.5) |
0.153 |
0.575 |
0.193 |
0.063 |
Back pain: Grade 1-2 |
12 (20.7) |
10 (16.7) |
17 (31.5) |
0.153 |
0.575 |
0.193 |
0.063 |
Dizziness/Headache: Grade 1-2 |
11 (19.0) |
12 (20.0) |
14 (25.9) |
0.629 |
0.887 |
0.377 |
0.451 |
Vaginal hemorrhage: Grade 1-2 |
11 (19.0) |
16 (26.7) |
25 (46.3) |
0.005 |
0.319 |
0.002 |
0.029 |
Abdominal pain: Grade 1-2 |
10 (17.2) |
3 (5.0) |
8 (14.8) |
0.099 |
0.034 |
0.727 |
0.076 |
Constipation: Grade 1-2 |
10 (17.2) |
5 (8.3) |
7 (13.0) |
0.350 |
0.146 |
0.528 |
0.421 |
Hypertension:
Grade 1-2
Grade 3
|
10 (17.2)
9 (15.5)
1 (1.7)
|
6 (10.0)
6 (10.0)
0 (0.0)
|
7 (13.0)
7 (13.0)
0 (0.0)
|
0.510
|
0.251
|
0.528
|
0.619
|
Alopecia: Grade 1-2 |
9 (15.5) |
9 (15.0) |
13 (24.1) |
0.376 |
0.938 |
0.255 |
0.220 |
Increased alanine aminotransferase: Grade 1-2 |
7 (12.1) |
1 (1.7) |
4
(7.4) |
0.085 |
0.025 |
0.407 |
0.188 |
Diarrhea: Grade 1-2 |
6 (10.3) |
2 (3.3) |
7 (13.0) |
0.165 |
0.130 |
0.666 |
0.082 |
Rash: Grade 1-2 |
6 (10.3) |
3 (5.0) |
12 (22.2) |
0.017 |
0.274 |
0.087 |
0.007 |
Dyspareunia: Grade 1-2 |
6 (10.3) |
5 (8.3) |
12 (22.2) |
0.066 |
0.707 |
0.087 |
0.038 |
Nausea: Grade 1-2 |
5 (8.6) |
3 (5.0) |
8 (14.8) |
0.193 |
0.487 |
0.306 |
0.076 |
Leukocytosis: Grade 1-2 |
5 (8.6) |
3 (5.0) |
5 (9.3) |
0.644 |
0.487 |
1.000 |
0.474 |
Pruritus: Grade 1-2 |
5 (8.6) |
1 (1.7) |
9 (16.7) |
0.018 |
0.111 |
0.198 |
0.005 |
Hypercoagulable status
Grade 1-2
|
2 (3.4)
|
0 (0.0)
|
1 (1.9)
|
0.359
|
0.147
|
1.000
|
0.474
|
Vomiting: Grade 1-2 |
1 (1.7) |
0 (0.0) |
3 (5.6) |
0.076 |
0.492 |
0.351 |
0.103 |
Thromboembolic event |
0 (0.0) |
0 (0.0) |
0 (0.0) |
/ |
/ |
/ |
/ |
Breast cancer |
0 (0.0) |
0 (0.0) |
0 (0.0) |
/ |
/ |
/ |
/ |