P-value showed the difference in total adverse events between different groups. Chi-square test was used, or Fisher exact test was performed when expect counts were less than 5.

^a Comparison between three groups;

^b Comparison between MA group and LNG-IUS group.

^c Comparison between MA group and MA+LNG-IUS group.

^d Comparison between LNG-IUS group and MA+LNG-IUS group.

P-value<0.05 was the significant threshold in analysis. Safety analyses were assessed in patients who received study drugs for more than 3 months. Eventually, 172 out of 180 patients were included.

Abbreviation: MA, megestrol acetate; LNG-IUS, levonorgestrel-releasing intrauterine system.