Materials and Methods
Patients with PCD who applied to the ENT outpatient clinic of our
tertiary center between January 2000 and December 2021 were
retrospectively evaluated. In patients with compatible clinical
findings, the diagnosis of PCD was mostly made by HSVA, while the rest
were made by nNO, TEM and genetic tests, respectively. Those with at
least 1 year of regular follow-up were included in this retrospective
cohort study. Demographic data, date of the first diagnosis,
diagnostician department, LRTI, acute/chronic otitis media with or
without effusion (AOM/COM/OME), ventilation tube insertion (VTI),
acute/chronic rhinosinusitis (ARS/CRS) histories, otoscopy, nasal,
adenoid, and tonsillar examination findings and audiogram results were
obtained from the hospital electronic database. Annual number of AOM and
ARS; age at first AOM, ARS, OME, COM, VTI, and CRS diagnoses were
recorded. The frequency of sinonasal and otological diseases, the
relationships between clinical and demographic data, and possible risk
factors for otolaryngological findings were investigated. Ethics
committee approval for this study was obtained from the Hacettepe
University Faculty of Medicine Non-interventional Clinical Researches
Ethics Board (Date: 18.01.2022, Decision number: 2022/02-12).
Statistical analyses were performed using IBM® SPSS
software version 25. Descriptive statistics were presented as frequency
(percent), mean±SD, or median (min-max). The χ2 test
was used to compare the proportions in different categorical groups.
Continuous variables were investigated with visual and analytical
methods to determine the normal distribution and analyzed with
Mann-Whitney U test or Student‘s t-test where appropriate. The
correlation coefficients and their significance were calculated using
the Spearman test. Odds ratios were determined by univariate logistic
regression analysis. A 5% type-I error level was used to infer
statistical significance.