Materials and Methods
Patients with PCD who applied to the ENT outpatient clinic of our tertiary center between January 2000 and December 2021 were retrospectively evaluated. In patients with compatible clinical findings, the diagnosis of PCD was mostly made by HSVA, while the rest were made by nNO, TEM and genetic tests, respectively. Those with at least 1 year of regular follow-up were included in this retrospective cohort study. Demographic data, date of the first diagnosis, diagnostician department, LRTI, acute/chronic otitis media with or without effusion (AOM/COM/OME), ventilation tube insertion (VTI), acute/chronic rhinosinusitis (ARS/CRS) histories, otoscopy, nasal, adenoid, and tonsillar examination findings and audiogram results were obtained from the hospital electronic database. Annual number of AOM and ARS; age at first AOM, ARS, OME, COM, VTI, and CRS diagnoses were recorded. The frequency of sinonasal and otological diseases, the relationships between clinical and demographic data, and possible risk factors for otolaryngological findings were investigated. Ethics committee approval for this study was obtained from the Hacettepe University Faculty of Medicine Non-interventional Clinical Researches Ethics Board (Date: 18.01.2022, Decision number: 2022/02-12).
Statistical analyses were performed using IBM® SPSS software version 25. Descriptive statistics were presented as frequency (percent), mean±SD, or median (min-max). The χ2 test was used to compare the proportions in different categorical groups. Continuous variables were investigated with visual and analytical methods to determine the normal distribution and analyzed with Mann-Whitney U test or Student‘s t-test where appropriate. The correlation coefficients and their significance were calculated using the Spearman test. Odds ratios were determined by univariate logistic regression analysis. A 5% type-I error level was used to infer statistical significance.