Disclosure Statement:
Dr. Izquierdo has nothing to disclose, Dr. C.R. Marion has nothing to disclose, Dr. Moore reports grants from NIH/NHLBI, grants from AstraZeneca, Boehringer-Ingelheim, Genentech, GlaxoSmithKline, Sanofi-Genzyme-Regeneron, and Teva during the conduct of the study; grants and personal fees from AstraZeneca, and Sanofi Regeneron, grants from Boehringer Ingelheim, GlaxoSmithKline, Novartis, Gossamer, and Cumberland Pharmaceuticals outside the submitted work; Karen Raraigh has nothing to disclose, Dr. Taylor-Cousar: received grants from Vertex Pharmaceuticals Incorporated, Gilead, N30, Celtaxsys, Proteostasis, and Bayer; has received fees from Vertex Pharmaceuticals Incorporated related to consultation on clinical research design, participation on advisory boards, and speaking engagements; has received speaking fees from Celtaxsys; and has served on advisory boards and/or provided consultation for Novartis, Genentech, Gilead, Protalix, Santhera, 4DMT, AbbVie, and Proteostasis; Dr. Cutting has nothing to disclose; Dr. Ampleford has nothing to disoclose; Dr. Hawkins has nothing to disclose, Dr.Zein has nothing to disclose, Dr. Castro receives University Grant Funding from NIH, American Lung Association, PCORI, Pharmaceutical Grant Funding from AstraZeneca, Chiesi, Novartis, GSK, Sanofi-Aventis; consultant fees for Genentech, Theravance, VIDA, Teva, Sanofi-Aventis, is a speaker for AstraZeneca, Genentech, GSK, Regeneron, Sanofi, & Teva, and receives Royalties from Elsevier; Dr. Denlinger has grants from NIH/NHLBI and has consulted with AstraZeneca and Sanofi-Regeneron during the conduct of the study; the extension of the longitudinal phase of the SARP cohort has also been supported by AstraZeneca, Boehringer-Ingelheim, Genentech, GSK, Sanofi-Genzyme-Regeneron, and TEVA; Dr. Erzurum reports grants from National Institutes of Health (NIH), during the conduct of the study; and Chair of the ABIM Pulmonary Disease Board; Dr. Fahy reports grants from NIH/NHLBI, grants from Boehringer Ingelheim during the conduct of the study; personal fees from Boehringer Ingelheim, Pieris, Arrowhead Pharmaceuticals, and Gossamer outside the submitted work, in addition, Dr. Fahy has a patent US20110123530A1 - “Compositions and methods for treating and diagnosing asthma” issued, a patent WO2014153009A2 -Thiosaccharide mucolytic agents. issued, and a patent WO2017197360 - “CT Mucus Score” - A new scoring system that quantifies airway mucus impaction using CT lung scans; Dr. Israel reports personal fees from AstraZeneca, Biometry, Entrinsic Health Solutions, Equillium, Genentech, GlaxoSmithKline, Merck, Novartis, 4D Pharma, Pneuma Respiratory, Regeneron Pharmaceuticals, Sanofi Genzyme, Sienna Biopharmaceutical, TEVA Specialty Pharmaceuticals, and Vitaeris, Inc; grants from AstraZeneca, Boehringer Ingelheim, Genentech, GlaxoSmithKline, Merck, Novartis, Sanofi, TEVA and Vifor-Pharma; non-financial support from Circassia, Boehringer Ingelheim, Genentech, GlaxoSmithKline, Merck, TEVA Specialty Pharmaceuticals and Vifor-Pharma; other from Vorso Corp, outside the submitted work; Dr. Jarjour has grants from NIH/NHLBI and has consulted with AstraZeneca and Boehringer Ingelheim, and during the extension of the longitudinal phase of the SARP cohort has also been supported, in part, by AstraZeneca, Boehringer-Ingelheim, Genentech, GSK, Sanofi-Genzyme-Regeneron, and TEVA; Dr. Mauger reports grant support from the NIH, AstraZeneca, Boehringer Ingelheim, Genentech, GSK, Sanofi-Genzyme-Regeneron, and Teva. L. C. Dr. Levy reports grants from NIH during the conduct of the study; other from Nocion Therapeutics, from Entrinsic Health, grants and personal fees from Sanofi, personal fees from Pieris Pharmaceuticals, Novartis, AstraZeneca, Corbus Pharmaceuticals, Gossamer Bio, Metera Pharmaceuticals, and Teva, and grants from Samsung Research America outside the submitted work; Dr. Wenzel reports grants from NIH and personal fees from AstraZeneca, grants and personal fees from GSK during the conduct of the study; grants and personal fees from Sanofi-Regeneron, grants from Boehringer Ingelheim ,Novartis, and TEVA, and personal fees from Pieris outside the submitted work; Dr. Woodruff is a consultant for Astra Zeneca, Theravance, Glenmark pharmaceuticals, Sanofi and Regeneron and has received funding from Genetech and the COPD Foundation, Dr. Bleecker reports other from NIH grant, clinical trials through his employer, Wake Forest School of Medicine and University of Arizona for AstraZeneca, MedImmune, Boehringer Ingelheim, Genentech, Johnson and Johnson (Janssen), Novartis, Regeneron, and Sanofi Genzyme, personal fees also serving as a paid consultant for AztraZeneca, MedImmune, Boehringer Ingelheim, Glaxo Smith Kline, Novartis, Regeneron, and Sanofi Genzyme outside the submitted work; Dr. Meyers has nothing to disclose; Dr. Ortega reports grants from NIH, personal fees from CSL Behring, outside the submitted work.