Hierarchical cluster analysis
Simultaneous ranking of the interventions in terms of efficacy(PGA0/1 or
IGA0/1) and safety(AEs) were summarized using a clustered–ranking
plot(Figure
3a).Cal/BD,betamethasone,
roflumilast and halobetasol formed a large cluster of topical therapies
with higher efficacy and safety. Tapinarof shows high
efficacy but lowest safety than
other treatments. Tofacitinib shows lower efficacy but highest safety
than other agents. Clustered ranking was applied to efficacy(PGA0/1 or
IGA0/1) and tolerability( Figure 3b)
.Cal/BD,betamethasone, roflumilast
and HP/TAZ presented in the top–right corner,were higher efficacy and
tolerability than orther agents.