Introduction
The central nervous system (CNS) is the second commonest site for
extragonadal germ cell tumours (GCT)1. Primary CNS
GCTs can be histologically divided into germinomas and non-germinomatous
GCTs (NG-GCTs), with the latter group comprising almost one third of
primary CNS GCTs2–5. Although germinomas are more
sensitive to chemotherapy and radiotherapy than NG-GCTs5–10, 75-82% of children with CNS NG-GCTs can still
be cured5. However, at relapse, most patients succumb
to their disease8,11–13. Hereby, we report the case
of an adolescent with a relapsed metastatic yolk sac tumour (YST) who
received multimodal treatment and remains alive and progression-free at
5 years from his last end of treatment. This encouraging case
contributes to the limited existing body of literature on the management
of relapsed CNS NG-GCT.