Introduction
The central nervous system (CNS) is the second commonest site for extragonadal germ cell tumours (GCT)1. Primary CNS GCTs can be histologically divided into germinomas and non-germinomatous GCTs (NG-GCTs), with the latter group comprising almost one third of primary CNS GCTs2–5. Although germinomas are more sensitive to chemotherapy and radiotherapy than NG-GCTs5–10, 75-82% of children with CNS NG-GCTs can still be cured5. However, at relapse, most patients succumb to their disease8,11–13. Hereby, we report the case of an adolescent with a relapsed metastatic yolk sac tumour (YST) who received multimodal treatment and remains alive and progression-free at 5 years from his last end of treatment. This encouraging case contributes to the limited existing body of literature on the management of relapsed CNS NG-GCT.