2.1. Patients
The plasma and tumor tissue samples of NB patients and corresponding
clinical data were collected from Children’s Hospital Affiliated to
Zhengzhou University. Inclusion criteria are as follows: (1)
histologically confirmed NB diagnosis; (2) assessment of MNA status by
FISH method; (3) availability of tumor and plasma samples; (4) written
informed consent from patients or their parents at the time of sample
collection. The research proposal was approved by the ethics review
committee of Children’s Hospital Affiliated to Zhengzhou University.