L-K score and nasal endoscopy
The reduction of L-K score in rh-bFGF nasal-drop group was significantly greater than in the control group 2 weeks(P3=0.004), 1 month(P3=0.004) and 1 year(P3=0.02) after ESS(Figure1I,J,L). The decrease in nasal-drop group at 1 month was still obvious, but the difference was not statistically significantly compared with control group(P3=0.09, Figure1K). The reduction of L-K score in rh-bFGF nasal-spray group was significantly greater than in the control group at 1 month(P2=0.001), 6 months(P2=0.02) and 1 year(P2=0.03) after ESS(Figure1J-L). The decrease in nasal-spray group at 2 weeks was still obvious, but the difference was not statistically significantly compared with control group(P2=0.13,Figure1I). Nasal endoscopy showed that reduced vesicles and purulent secretion occurred in the rh-bFGF experimental groups than that in control group at 2 weeks(Figure2B,G,L). This trend was even more pronounced 1 month after ESS. Partial nasal mucosal epithelialization was observed in rh-bFGF experimental groups(Figure2C,H,M). Rh-bFGF experimental groups almost eliminated edema and completed epithelialization at 6 months and 1 year(Figure2D,E,I,J,N,O).