What this study adds
A CRMP2-derived peptide (CBD3) uncouples the Cav2.2-CRMP2 interaction to inhibit calcium influx, neurotransmission, and pain.
The peptidomimetic CBD3063 blocks Cav2.2 activity, uncouples the Cav2.2-CRMP2 interaction, and reverses neuropathic pain.