3.4 TVM reduced the threshold pressure
Next, we assayed the impact of TVM on the compliance-associated
parameters, namely the infused volume (Vinf) and the threshold pressure
(Pthd; the maximal detrusor pressure at the end of the filling stage)
because Cm is defined as Vinf/Pthd. When compared with the pre-operative
control, TVM did not result in a consistent trend of increase/decrease
in the infused volume (Figure 4A Vinf, 8/14 out of 22 patients; 36/64%,
respectively). Moreover, no statistical difference was evidenced between
the mean value of Vinf measured pre- and post-operatively (Figure 4B
p>0.05, N=22).
On the other hand, TVM consistently decreased Pthd in most patients
(Figure 4C; 18 out of 22, 82%) and significantly decreased the mean
value of Pthd of the patient when compared with the pre-operative
control (Figure 4D p<0.01, N=22). Collectively, these findings
reveal TVM-decreased compliance was resulted from reduced pressure with
minimal affected infused volume during bladder filling.