3.4 TVM reduced the threshold pressure
Next, we assayed the impact of TVM on the compliance-associated parameters, namely the infused volume (Vinf) and the threshold pressure (Pthd; the maximal detrusor pressure at the end of the filling stage) because Cm is defined as Vinf/Pthd. When compared with the pre-operative control, TVM did not result in a consistent trend of increase/decrease in the infused volume (Figure 4A Vinf, 8/14 out of 22 patients; 36/64%, respectively). Moreover, no statistical difference was evidenced between the mean value of Vinf measured pre- and post-operatively (Figure 4B p>0.05, N=22).
On the other hand, TVM consistently decreased Pthd in most patients (Figure 4C; 18 out of 22, 82%) and significantly decreased the mean value of Pthd of the patient when compared with the pre-operative control (Figure 4D p<0.01, N=22). Collectively, these findings reveal TVM-decreased compliance was resulted from reduced pressure with minimal affected infused volume during bladder filling.