4.2.2. Angiotensin-converting enzyme-2 (ACE-2)
ACE-2 is the functional receptor of the COVID-19 virus. It is a negative
regulator of the Renin-Angiotensin System (RAS) . It is seen that the S
protein of the virus will bind to this receptor located on the host cell
with great affinity thereby resulting in higher pathogenicity .
Therefore, by making use of some sort of inhibitor or blocking agent
ACE-2 becomes a potential therapeutic target in the treatment
ofCOVID-19. It is possible to employ viral neutralizing antibodies as
they are assumed to be the receptor-binding domain (RBD) specific and
can play a role in neutralizing the viral particles .Some natural
compounds have displayed a good binding affinity towards ACE-2 such as
Amentoflavone, Chysanthemin, and Biovobin.