4.3.1.4. Chloroquine
Chloroquine falls under the category of aminoquinolines and is a
wide-spectrum antiviral drug. It has been used to treat malaria as well
as autoimmune disease such as lupus erythematosus, rheumatoid arthritis
and is an anti-inflammatory agent . It is seen to mainly inhibit the
entry, post entry, and transport phases of the COVID-19 virus . This
drug essentially inhibits the binding of S protein to the ACE-2 receptor
located on the host cell and hence will inhibit replication of the RNA,
the glycosylation of the viral proteins, the assembly of the virus, and
finally exocytosis . This drug was given emergency use authorization by
the US FDA for the treatment of COVID-19 patients .