4.2.1. RNA-Dependent RNA Polymerase (RdRp)
RdRp is also called Nsp12 . It is an essential enzyme for the
replication and transcription of the virus. So, the inhibition of this
enzyme forms one of the possible treatment strategies. A recent study
showed that this drug target was associated with a safer profile, less
toxicity, and fewer side effects . Drugs such as Ribavirin, Remdesivir,
Cortisone, Idarubicin, and Pancuronium bromide have been observed to act
upon this protein . In addition, there are a wide array of natural
compounds that act on RdRp and have shown anti-COVID activity including
Gnidicin from Gnidialamprantha and Betulonal fromCassinexyloacarpa . However, more studies are required to
substantiate its efficacy in higher populations.