4.2.1. RNA-Dependent RNA Polymerase (RdRp)
RdRp is also called Nsp12 . It is an essential enzyme for the replication and transcription of the virus. So, the inhibition of this enzyme forms one of the possible treatment strategies. A recent study showed that this drug target was associated with a safer profile, less toxicity, and fewer side effects . Drugs such as Ribavirin, Remdesivir, Cortisone, Idarubicin, and Pancuronium bromide have been observed to act upon this protein . In addition, there are a wide array of natural compounds that act on RdRp and have shown anti-COVID activity including Gnidicin from Gnidialamprantha and Betulonal fromCassinexyloacarpa . However, more studies are required to substantiate its efficacy in higher populations.