Alpha |
B.1.1.7 |
Spike Protein mutations N501Y, D614G, P681H |
Increased transmissibility and severity |
30-40% higher compared to
wild type |
Responsible for the UK’s 2nd wave |
Kent
UK in Sept 2020 |
|
Beta |
B.1.351 |
Non synonymous mutation in the Lys417 located in the
RBD of S glycoprotein at K417N position |
Increased transmissibility and
reduced sensitivity to neutralizing antibodies |
50% higher compared to
wild type |
2nd wave |
South Africa in Oct 2020 |
|
Gamma |
P.1 |
E484K and N501Y H655Y |
Increased transmissibility,
possible increased severity |
1.7-2.4 times higher in comparison to wild
type |
2nd wave |
Jan 2021in Brazilian travelers in
Japan |
|
Delta |
B.1.617.2 |
E484Q and L452R mutations in spike protein |
Increased infectivity and severity, highly transmissible |
60% more
than alpha |
Prominent in 2nd and also seen in
3rd wave |
Dec 2020 in India |
|
Omicron |
B.1.1.529 |
32 mutations in spike protein |
Increased
transmissibility |
3 times more than wild type |
3rd
wave |
Nov 2021 in South Africa |
|