4.3.1.3. Lopinavir/Ritonavir
Lopinavir/Ritonavir are antiretroviral protease inhibitors. These drugs are generally found in combination with each other commercially. Ritonavir is seen to be a boosting agent to Lopinavir and limits the drug’s metabolism thereby improving its bioavailability . They are specific to HIV protease-1 and have been used in the treatment of HIV infection . A recent study conducted by Pandey et al., showed that a combination of Lopinavir/Ritonavirwas not effective for the treatment of the Middle East respiratory syndrome (MERS) and SARS-COV. However, it showed promising efficacy in the treatment of COVID-19 . Thus, more studies need to be carried out to provide concrete evidence of the use of this combination in the treatment of COVID-19.