4.3.1.3. Lopinavir/Ritonavir
Lopinavir/Ritonavir are antiretroviral protease inhibitors. These drugs
are generally found in combination with each other commercially.
Ritonavir is seen to be a boosting agent to Lopinavir and limits the
drug’s metabolism thereby improving its bioavailability . They are
specific to HIV protease-1 and have been used in the treatment of HIV
infection . A recent study conducted by Pandey et al., showed that a
combination of Lopinavir/Ritonavirwas not effective for the treatment of
the Middle East respiratory syndrome (MERS) and SARS-COV. However, it
showed promising efficacy in the treatment of COVID-19 . Thus, more
studies need to be carried out to provide concrete evidence of the use
of this combination in the treatment of COVID-19.