Title Page
The effect of the plasma methotrexate concentration during high-dose
methotrexate therapy on prognosis of childhood acute lymphoblastic
leukemia
Running title: Methotrexate concentration and prognosis
Chan Liao, Xiao-Jun Xu, Jing-Ying Zhang, Hua Song, Wei-Qun Xu, He-Ping
Shen, Di-Ying Shen, Fen-Ying Zhao, Juan Liang, Yong-Min Tang*.
Department of Pediatric Hematology-Oncology, The Children’s Hospital,
Zhejiang University School of Medicine, the Pediatric Leukemia
Diagnostic and Therapeutic Technology Research Center of Zhejiang
Province, National Clinical Research Center for Child Health. #57
Zhuganxiang Road, Yan-an Street, Hangzhou, China.
* Corresponding author: E-mail: y_m_tang@zju.edu.cn. Tel: +86
571 88873450; Fax: +86 571 87033296.
Principal Investigator statement: The authors confirm that the
Principal Investigator for this paper is Chan Liao and that she had
direct clinical responsibility for patients.
Keywords: methotrexate, pharmacokinetics, pharmacogenomics,
childhood, survival, acute lymphoblastic leukemia