The probability of ABO incompatibility
A total of 85 590 blood donors in Qingdao, Shandong Province were
recruited from the Affiliated Hospital of Qingdao University between May
2018 and November 2019. EDTA-anti-coagulated peripheral blood samples
were obtained from all enrolled participants, and standard serological
typing methods were used to test their blood types for ABO antigens and
antibodies. All participants were negative for irregular antibodies.
This study protocol was approved by the ethics committee of the
Affiliated Hospital of Qingdao University.
According to Akanmu. A.S. et al. [13], the ABO blood-group gene
frequencies of the population are calculated using data for the
prevalence of blood group phenotype obtained from ABO typing of blood
donors based on the Hardy-Weinberg equilibrium. Further, the occurrence
rates of OO and non-OO (AA, BB, AO, and BO) blood type genotypes in the
population were obtained. The possibility of ABO incompatibility is the
sum of the product of the probability that the father of blood group
genotypes is non-OO combined with the probability that the mother is OO.