The probability of ABO incompatibility
A total of 85 590 blood donors in Qingdao, Shandong Province were recruited from the Affiliated Hospital of Qingdao University between May 2018 and November 2019. EDTA-anti-coagulated peripheral blood samples were obtained from all enrolled participants, and standard serological typing methods were used to test their blood types for ABO antigens and antibodies. All participants were negative for irregular antibodies. This study protocol was approved by the ethics committee of the Affiliated Hospital of Qingdao University.
According to Akanmu. A.S. et al. [13], the ABO blood-group gene frequencies of the population are calculated using data for the prevalence of blood group phenotype obtained from ABO typing of blood donors based on the Hardy-Weinberg equilibrium. Further, the occurrence rates of OO and non-OO (AA, BB, AO, and BO) blood type genotypes in the population were obtained. The possibility of ABO incompatibility is the sum of the product of the probability that the father of blood group genotypes is non-OO combined with the probability that the mother is OO.