References
  1. Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized patients with 2019 Novel Coronavirus-Infected pneumonia in Wuhan, China. JAMA- J Am Med Assoc. 2020. doi:10.1001/jama.2020.1585.
  2. Kuba K, Imai Y, Rao S, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med. 2005. doi:10.1038/nm1267.
  3. Letko M, Marzi A, Munster V. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B beta coronaviruses. Nat Microbiol. 2020. doi: 10.1038/s41564-020-0688-y.
  4. Chiappelli F. putative Natural History of CoViD-19. Bioinformation. 2020. doi: 10.6026/97320630016398.
  5. Mao L, Wang M, Chen S, et al. Neurological Manifestations of Hospitalized patients with COVID-19 in Wuhan, China: A Retrospective Case Series Study. SSRN Electron J. 2020. doi:10.2139/ssrn.3544840.
  6. Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMpRSS2 and Is Blocked by a Clinically proven protease Inhibitor. Cell. 2020. doi:10.1016/j.cell.2020.02.052.
  7. Abiodun OA, Ola MS. Role of brain renin angiotensin system in neurodegeneration: An update. Saudi J Biol Sci. 2020. doi: 10.1016/j.sjbs.2020.01.026.
  8. 8.Netter FH, Craig JA, perkins J. Atlas of Neuroanatomy and Neurophysiology. Netter Collect Med Illus. 2002. doi: 10.1093/brain/awf218.
  9. Netland J, Meyerholz DK, Moore S, Cassell M, perlman S. Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2. J Virol. 2008. doi:10.1128/jvi.00737-08.
  10. Dubé M, Le Coupanec A, Wong AHM, Rini JM, Desforges M, Talbot pJ. Axonal Transport Enables Neuron-to-Neuron propagation of Human Coronavirus OC43. J Virol. 2018. doi:10.1128/jvi.00404-18.
  11. 11.Nogués MA, Benarroch E. Respiratory control disorders and respiratory motor unit. Neurol Argentina. 2011. doi:10.1016/j.neuarg. 2011.05.006.
  12. Yan CH, Faraji F, prajapati Dp, Boone CE, DeConde AS. Association of chemosensory dysfunction and Covid-19 in patients presenting with influenza-like symptoms. Int Forum Allergy Rhinol. 2020. doi:10.1002/alr.22579.
  13. Menni C, Valdes A, Freydin MB, et al. Loss of smell and taste in combination with other symptoms is a strong predictor of COVID-19 infection. medRxiv. 2020. doi:10.1101/2020. 04.05.20048421.
  14. Doty RL. The olfactory vector hypothesis of neurodegenerative disease: is it viable? Ann Neurol. 2008 Jan;63(1):7-15. doi: 10.1002/ana.21327. PMID: 18232016.
  15. Li K, Wohlford-Lenane C, perlman S, et al. Middle east respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4. J Infect Dis. 2015. doi:10.1093/ infdis/jiv499.
  16. Moein ST, Hashemian SM, Mansourafshar B, Khorram-Tousi A, Tabarsi P, Doty RL. Smell dysfunction: a biomarker for COVID-19. Int Forum Allergy Rhinol. 2020 Aug;10(8):944-950. doi: 10.1002/alr.22587. Epub 2020 Jun 18. PMID: 32301284; PMCID: PMC7262123.