2- Clinical and biochemical index
The most common observed laboratory abnormalities related to SARS-CoV-2
are hypoalbuminemia, lymphopenia, decreased percentage of lymphocytes
and neutrophils, elevated levels of C-reactive protein (CRP) and lactate
dehydrogenase (LDH), as well as decreased CD8 count. The viral load of
SARS-CoV-2, detected through the respiratory tracts of patients, has
been reported to be positively linked to the lung disease severity.
Albumin, lymphocytes, LDH, neutrophils, and CRP are highly correlated
with the acute lung injury. Age, viral load, lung injury score, and
blood biochemistry indices, Albumin, CRP, LDH, lymphocytes (%), and
neutrophils (%), are possibly the predictors of disease severity.
Moreover, the angiotensin II level in the plasma samples of SARS-CoV-2
infected patients is markedly higher than its normal level, being
linearly associated with the viral load and lung injury (Y. Liu et al.,
2020). Non-survivors had higher levels of neutrophils, D-Dimer, blood
urea nitrogen, and creatinine, compared to the survivors (D. Wang et
al., 2020) (Fig. 1).