2.4 Definitions
Complete remission (CR) was defined as no circulating lymphoblasts or
extramedullary disease, bone marrow with trilineage hematopoiesis and
less than 5% blasts, neutrophil counts of more than 1 ×
109/L, platelet counts of more than 100 ×
109/L, and no recurrence for 4
weeks.23 Relapse was defined as the recurrence of
higher than 5% BM blasts, the reappearance of blasts in the blood, or
the development of extramedullary disease infiltrates at any site.
Relapse-free survival (RFS) was measured from the date when CR was
achieved to relapse.
Overall
survival (OS) was measured from diagnosis to death (regardless of cause)
or last follow-up.