Acknowledgements
I would like to express my very great appreciation to Dr. Touraine Renaud, Head of génétique clinique, chromosomique et moléculaire, CHU Saint-Etienne, Saint Priez en Jarez, France for his valuable and constructive suggestions during this research work and for allowing me to use the department’s instrumentation. Also, I thank patients and their families for their collaboration
Ethical considerations were followed in agreement with the Declaration of Helsinki throughout this study and it was approved by the Research Committee/ Center hospital university, Faculty of medicine, University of Jean Monnet, Saint Etienne, France.
Consent was given by all the control participants.
Consent was given by the Legally authorized representatives/next of kin of the Down’s Syndrome participants (vulnerable population).
Conflict of interest: None declared