Fig. 5. Acute phase response signaling. a. IPA mined acute
phase response network overlaid with protein expression data from the
plasma protein dataset. Green signifies down-regulation and pink/red
signifies up-regulation of proteins. b. Interplay between lipid
metabolism, inflammation and coagulation system. Upstream regulators
identified across groups using IPA. RXR is observed to interact with
HNF4A, apolipoproteins, coagulation proteins, cytoskeletal proteins and
complement proteins thus suggesting interplay of lipid metabolism,
cytoskeleton, coagulation system and inflammation. c.Immunoblots of relevant acute phase proteins involved in lipid
metabolism, complement system, coagulation system and redox homeostasis.
Results represented as Mean±SEM. *p-value<0.05.