Fig. 3. a. Actin cytoskeleton signaling pathway. IPA mined
Actin cytoskeleton network overlaid with protein expression data from
the lung protein dataset. Green signifies down-regulation and pink/red
signifies up-regulation of proteins. b. Role of STAT3 in
modulation of energy metabolism, structural proteins and antioxidant
proteins. IPA based integrated network for HD3, HD7 and HD14 datasets
(using lung proteome expression data) showed STAT3 as the upstream
regulator. c. Representative immunoblots of key lung proteins
along with equal loading gel (Fig. S6: loading control; Supplementary
information) and d. their bar-graphs. Results presented as
Mean±SEM. *p-value<0.05.