Fig. 4. a. Overview of the identified differentially expressed SD rat plasma proteins. b. Pie chart showing the most significant molecular and cellular processes across hypoxic groups using normalized protein fold change values. c. Hierarchical clustergram of identified plasma proteins using normalized fold change values. Green is down-regulated and red is up-regulated d. IPA based analysis of the most significant pathways as well their overall directionality based on z-scores (orange: up-regulation; blue: down-regulation; white: neutral; grey: no directionality).