Fig. 5. Acute phase response signaling. a. IPA mined acute phase response network overlaid with protein expression data from the plasma protein dataset. Green signifies down-regulation and pink/red signifies up-regulation of proteins. b. Interplay between lipid metabolism, inflammation and coagulation system. Upstream regulators identified across groups using IPA. RXR is observed to interact with HNF4A, apolipoproteins, coagulation proteins, cytoskeletal proteins and complement proteins thus suggesting interplay of lipid metabolism, cytoskeleton, coagulation system and inflammation. c.Immunoblots of relevant acute phase proteins involved in lipid metabolism, complement system, coagulation system and redox homeostasis. Results represented as Mean±SEM. *p-value<0.05.