Fig. 6. Process specific proteins in humans undergoing extended low pO2 exposure. ELISA results fora. S100A8, b. Cofilin 1 (CFL 1) and c.alpha-1-antitrypsin (α-1-AT) in human plasma samples after 7, 30 and 120 days at 14,000 ft (pO2 12.81 kPa) represented as Mean±SEM. *p-value<0.05. **p-value<0.01. Across rat model and humans exposed to low pO2 for extended durations, qualitative similarities exist as shown by perturbed inflammation cascades (S100A8) and cyto-skeletal re-arrangements (CFL 1 and α-1-AT).