Fig. 3. a. Actin cytoskeleton signaling pathway. IPA mined Actin cytoskeleton network overlaid with protein expression data from the lung protein dataset. Green signifies down-regulation and pink/red signifies up-regulation of proteins. b. Role of STAT3 in modulation of energy metabolism, structural proteins and antioxidant proteins. IPA based integrated network for HD3, HD7 and HD14 datasets (using lung proteome expression data) showed STAT3 as the upstream regulator. c. Representative immunoblots of key lung proteins along with equal loading gel (Fig. S6: loading control; Supplementary information) and d. their bar-graphs. Results presented as Mean±SEM. *p-value<0.05.