Effect of T1DM on Childhood Asthma
A total of 28 T1DM-associated SNPs were selected based on GWAS analysis
in the National Human Genome Research Institute (NHGRI) and the European
Bioinformatics Institute (EBI) GWAS Catalog
(https://www.ebi.ac.uk/gwas/) (Table S2).15-21The F-statistic ranges from 107 to 559 and could strongly predict T1DM
(F>10). LD-clumping were applied to remove dependent SNPs
and 20 of them were available in the outcome dataset. Effect estimates
of T1DM-associated SNPs on the risk of childhood were assessed using the
FinnGen study (992 childhood asthma cases and 65,481 controls of
European ancestry).