Reference
1. French CA, Kutok JL, Faquin WC, et al: Midline carcinoma of children and young adults with NUT rearrangement. J Clin Oncol 22:4135-9, 2004
2. French CA: Pathogenesis of NUT midline carcinoma. Annu Rev Pathol 7:247-65, 2012
3. French CA: NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatment. Pathol Int 68:583-595, 2018
4. Kubonishi I, Takehara N, Iwata J, et al: Novel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinoma. Cancer Res 51:3327-8, 1991
5. French CA, Miyoshi I, Kubonishi I, et al: BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res 63:304-7, 2003
6. Bauer DE, Mitchell CM, Strait KM, et al: Clinicopathologic features and long-term outcomes of NUT midline carcinoma. Clin Cancer Res 18:5773-9, 2012
7. Chau NG, Hurwitz S, Mitchell CM, et al: Intensive treatment and survival outcomes in NUT midline carcinoma of the head and neck. Cancer 122:3632-3640, 2016
8. Dutta R, Nambirajan A, Mittal S, et al: Cytomorphology of primary pulmonary NUT carcinoma in different cytology preparations. Cancer Cytopathol 129:53-61, 2021
9. den Bakker MA, Beverloo BH, van den Heuvel-Eibrink MM, et al: NUT midline carcinoma of the parotid gland with mesenchymal differentiation. Am J Surg Pathol 33:1253-8, 2009
10. Shehata BM, Steelman CK, Abramowsky CR, et al: NUT midline carcinoma in a newborn with multiorgan disseminated tumor and a 2-year-old with a pancreatic/hepatic primary. Pediatr Dev Pathol 13:481-5, 2010
11. Liu S, Ferzli G: NUT carcinoma: a rare and devastating neoplasm. BMJ Case Rep 2018, 2018
12. Salati M, Baldessari C, Bonetti LR, et al: NUT midline carcinoma: Current concepts and future perspectives of a novel tumour entity. Crit Rev Oncol Hematol 144:102826, 2019
13. Huang QW, He LJ, Zheng S, et al: An Overview of Molecular Mechanism, Clinicopathological Factors, and Treatment in NUT Carcinoma. Biomed Res Int 2019:1018439, 2019
14. Benito Bernaldez C, Romero Munoz C, Almadana Pacheco V: NUT midline carcinoma of the lung, a rare form of lung cancer. Arch Bronconeumol 52:619-621, 2016
15. Sholl LM, Nishino M, Pokharel S, et al: Primary Pulmonary NUT Midline Carcinoma: Clinical, Radiographic, and Pathologic Characterizations. J Thorac Oncol 10:951-9, 2015
16. Parikh SA, French CA, Costello BA, et al: NUT midline carcinoma: an aggressive intrathoracic neoplasm. J Thorac Oncol 8:1335-8, 2013
17. Xie XH, Wang LQ, Qin YY, et al: Clinical features, treatment, and survival outcome of primary pulmonary NUT midline carcinoma. Orphanet J Rare Dis 15:183, 2020
18. Lantuejoul S, Pissaloux D, Ferretti GR, et al: NUT carcinoma of the lung. Semin Diagn Pathol, 2021
19. Giridhar P, Mallick S, Kashyap L, et al: Patterns of care and impact of prognostic factors in the outcome of NUT midline carcinoma: a systematic review and individual patient data analysis of 119 cases. Eur Arch Otorhinolaryngol 275:815-821, 2018
20. Piha-Paul SA, Hann CL, French CA, et al: Phase 1 Study of Molibresib (GSK525762), a Bromodomain and Extra-Terminal Domain Protein Inhibitor, in NUT Carcinoma and Other Solid Tumors. JNCI Cancer Spectr 4:pkz093, 2020
21. Stathis A, Zucca E, Bekradda M, et al: Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628. Cancer Discov 6:492-500, 2016
22. Lee JK, Louzada S, An Y, et al: Complex chromosomal rearrangements by single catastrophic pathogenesis in NUT midline carcinoma. Ann Oncol 28:890-897, 2017
23. French CA: Demystified molecular pathology of NUT midline carcinomas. J Clin Pathol 63:492-6, 2010
24. 刘小琴, 李艳莹, 余敏, et al: 肺NUT癌1例报告及文献复习. 中国肺癌杂志 24:63-68, 2021
FIGURE LEGEND
Fig. 1 Serial abdominal CT scans shows dynamic change from the base line to the radiation. a1 the base line of the metastatic mediastinal lymph nodes a2 a3 the base line of the primary tumor at the left lung. b1 after two cycles of chemotherapy with TC(taxol and carboplatin), the metastatic mediastinal lymph nodes shrink but a new metastatic lymph node occur. b2 b3 the primary tumor partly shrink. c1 after radiotherapy, the all the metastatic lymph nodes obviously shrink. c2 c3 the primary tumor totally shrink.
Fig. 2 Histopathological examination shows poorly differentiated squamous cell mixture TTF1(+) and SYN(+) cells which small neuroendocrine cell carcinoma could not been excepted. A, (× 200); B (× 100);
Fig. 3 Serial abdominal CT scans shows dynamic change of the follow-up treatment and the last period. a1 a2 after 4 cycles of immunotherapy with durvalumab, the mediastinal lymph nodes did not recur. a3 the primary tumor at the left lung recur and a new mass occur at the right low lung. b2 after two cycles of chemotherapy with EP(etoposide and cis-platinum) and anti-angiogenesis agent anlotinib, the mediastinal lymph nodes have no change compared before. b1 b3 the primary tumor progressed fastly. c1 c2 at the last period, the pleural effusion and the pericardial effusion appeared.
Fig. 4 Overview of the whole treatment process.
Supplement figs1 the target volume of this case was preventability lymph node area radiation.
Supplement figs2 the CT scan images of the male from the base line to the last period.
Supplement figs3 the CT scan images of the female from the base line to the last period show the disaster nut lung cancer progressed so fast that there is no chance to treat.