Abstract
Aims: The present study was conducted to evaluate the safety of
celery seed extract (Apium graveolens ), as a medicinal herb with
active ingredients such as 3-n-butylphthalide (NBP), in hypertensive
patients.
Methods: This study was a randomized, triple-blind,
placebo-controlled, cross-over clinical trial. Hypertensive patients (51
participants) received 4 celery seed capsules (a total of 1.34g extract
per day) or 4 placebo capsules per day for 4-weeks as a supplement to
their usual medication regimen.
Results: The results indicated that the celery seed capsule not
only was safe for hypertensive patients but caused a reduction in BP,
FBS, and lipid profile values. Also, it had beneficial effects on kidney
and liver functions. No significant change was observed in blood cells
and serum electrolytes (P>0.05). The mean reduction in BUN
and SCr were 3.43 and 0.075 mg/dL, and in SGPT and SGOT were 4.08 and
3.03 U/L, respectively (P<0.05). FBS reduced from 108.53 to
97.96 mg/dL after 4-weeks of celery administration (P<0.01).
The decrease in TC, TG, LDL, and increase in HDL were 16.37, 16.22,
11.84, and 2.52 mg/dL, respectively (P<0.001).
Conclusions: According to the promising results of this
clinical trial, celery seed extract can be considered a safe supplement
for hypertensive patients.
Trial registration number and date of registration:
IRCT20130418013058N8, 2018-04-22
Keywords: Celery Capsules, Cross-Over Clinical Trial, Drug
Supplement, Herbal Medicine, Safety Evaluation, Hypertensive
patients