Conclusion
In conclusion, our study identified cut-off points of the sFlt-1/PlGF
ratio to indicate the presence of different subsets of PE features among
the singleton pregnancies with symptoms of hypertension. Our results
suggested that, maternal serum sFlt-1/PlGF ratios of 37 and 48 had the
potential to identify the patients with higher risk of developing early
onset PE features from gestational and chronic hypertension,
respectively, whcih could complement the HDP management strategies.
Different sFlt-1/PIGF cut-off value should be employed in women with
HDP, and the intensity of monitor and management of care-givers aided to
PE occurrence should change accordingly for better maternal and prenatal
outcomes.
Disclosure of interest:
None of the members of the research group reports a conflict of
interest.
Details of ethics approval
The study was approved on 1 March 2017 by the Institutional Ethics
Committee of Guangzhou Women and Children’s Medical Center (Reference
number: 2017022008).
Funding
This study was supported by Guangzhou science and technology Program
Project (202102010163) .
Acknowledge
The authors thank all the patients who donated their blood samples for
scientific research in the Guangzhou Women and Children’s Medical
Center.