Conclusion
In conclusion, our study identified cut-off points of the sFlt-1/PlGF ratio to indicate the presence of different subsets of PE features among the singleton pregnancies with symptoms of hypertension. Our results suggested that, maternal serum sFlt-1/PlGF ratios of 37 and 48 had the potential to identify the patients with higher risk of developing early onset PE features from gestational and chronic hypertension, respectively, whcih could complement the HDP management strategies. Different sFlt-1/PIGF cut-off value should be employed in women with HDP, and the intensity of monitor and management of care-givers aided to PE occurrence should change accordingly for better maternal and prenatal outcomes.
Disclosure of interest:
None of the members of the research group reports a conflict of interest.
Details of ethics approval
The study was approved on 1 March 2017 by the Institutional Ethics Committee of Guangzhou Women and Children’s Medical Center (Reference number: 2017022008).
Funding
This study was supported by Guangzhou science and technology Program Project (202102010163) .
Acknowledge
The authors thank all the patients who donated their blood samples for scientific research in the Guangzhou Women and Children’s Medical Center.