Figure 4. Measurement of IFN-γ production to determine SARS-CoV-2-specific T cell responses in individuals pre- and post-vaccination.
(A) IFN-γ release in response to overnight stimulation with the SARS-CoV-2 peptide pool in previously unexposed individuals pre- and post-vaccination (●=pre-vaccination, ●=1stvaccination, ●=2nd vaccination). Square symbol=Janssen vaccine (A only). Results show arithmetic mean +/-SEM. Dashed line = positivity cut off. *p<0.05, **p<0.01, ns = not significant. (B) ROC curves defining sensitivity and specificity for IFN-γ. AUC and associated P value are indicated.