Correlation of Immune Infiltrates in CC
We further assessed the interrelationships of immune stains by analyzing
the correlation of pairwise markers. By unsupervised hierarchical
clustering, Pearson correlation coefficients (R ) was showed in
the two groups heatmaps which respectively revealed a dominant array of
co-regulated markers, including CD3, CD8, CD56, CD68, PD1 and PD-L1
(Figure 4AC).
With pLN metastasis, the correlation were enhanced between CD3 and CD8
(R =0.51, P <0.0001), CD3 and CD68 (R =0.38,P <0.001), CD8 and CD56 (R =0.92, P <0.001), CD8 and
CD68 (R =0.47, P <0.001), CD8 and PD-1 (R =0.42,P <0.001), CD68 and PD-1 (R =0.35, P <0.001) (Figure
4BD).