Main findings
This study shows that the Gaussian and FMF algorithms have similar
predictive accuracies for PE and SGA, except for early-onset PE, where
the FMF algorithm showed a significantly lower AUC with the combinations
of MAP and PAPP-A, MAP and PlGF, and MAP alone. These significant
differences could be partly attributed to the different methodology
required for MAP assessment in both algorithms. In this study, MAP was
measured once, in only one arm and after a 5-minute rest, while the FMF
algorithm was designed with an average of two MAP measurements performed
at 1-minute intervals in both arms simultaneously after a 5-minute
rest21. This different methodology for MAP
measurements may have affected the accuracy of all combinations
including MAP in the FMF algorithm, but especially MAP alone or those
combinations including MAP with one other factor.