Introduction
Pancreatic neuroendocrine tumors (PNETs) are a heterogeneous group of
tumors that arise from the endocrine tissues of the pancreas and
comprise only 1%–2% of pancreatic tumors [1,2]. However, their
incidence has significantly increased over the past few decades due to
the improvement and the wide-spread use of diagnostic imaging [3] .
Only 10% of all PNETS are associated with hereditary genetic endocrine
tumor syndromes, other cases are sporadic[4,5].
PNETs are classified as functional or non-functional tumors depending on
the presence of clinical syndrome caused by the hypersecreted hormones
and in most of cases they are non-functional [6].
Aggressiveness of these tumors is very unpredictable ranging from
slow-growing to invasive forms [7].
Metastatic disease mostly affects liver, lymph nodes and bones [8].
Ocular metastases from neuroendocrine tumors are exceedingly rare and
can simulate other primary or metastatic lesions [9]. We report a
case of pancreatic neuroendocrine carcinoma revealed by choroidal
metastasis.
We report a particular observation of a 61-year-old man in whom
choroidal metastasis was the revealing manifestation of a metastatic
pancreatic neuroendocrine carcinoma.