Recommendations for Genetic Testing
Genetic testing in AF carries multiple potential benefits, including
early identification of patients who are at high risk for
developing an associated cardiomyopathy and in whom intensified
surveillance may be warranted.82 Based on the current
available data, we suggest consideration of genetic testing in selected
subsets of the AF population (Figure 2):
- Patients with lone AF, defined as <66 years of age at time
of AF diagnosis and in the absence of structural heart disease
- Patients without clinical risk factors for AF, such as hypertension,
chronic kidney disease, or diabetes
- Patients with AF and family history of ICD implantation
- Patients with AF and family history of sudden cardiac death
- Patients with AF and who have multigenerational family history of
AF83