CLINICAL TESTING CONSIDERATIONS
Despite the plethora of data supporting genetic risk analysis for the prediction of AF and increasingly available commercial genetic tests, contemporary guidelines do not recommend routine genetic testing for all-comers with AF. The 2014 American Heart Association, American College of Cardiology, and the Heart Rhythm Society guidelines provide a class IIb recommendation for consideration of genetic testing in patients with AF and multigenerational familial AF.19This is clarified in the Heart Rhythm Society and the European Heart Rhythm Association consensus statement by citing a lack of actionable evidence on how genetic analyses, which have largely focused on AF prediction, will impact clinical AF outcomes.69