CLINICAL TESTING CONSIDERATIONS
Despite the plethora of data supporting genetic risk analysis for the
prediction of AF and increasingly available commercial genetic tests,
contemporary guidelines do not recommend routine genetic testing for
all-comers with AF. The 2014 American Heart Association, American
College of Cardiology, and the Heart Rhythm Society guidelines provide a
class IIb recommendation for consideration of genetic testing in
patients with AF and multigenerational familial AF.19This is clarified in the Heart Rhythm Society and the European Heart
Rhythm Association consensus statement by citing a lack of actionable
evidence on how genetic analyses, which have largely focused on AF
prediction, will impact clinical AF outcomes.69