Citation Variant in Gene/Locus Study Population Outcome Analyzed Result
Wu G, et al.89
IL6R
AAD-refractory AF, Chinese population
Early (within 1 month) and late (within 1 year) recurrence after catheter ablation
Early: OR 1.84 (95% CI 1.31-2.59, p=4.10x10-4) Late: OR 1.92 (95% CI 1.30-2.81, p=0.001)
Cao H, et al.90 RANKL Lone AF, Chinese population Recurrence after first-time catheter ablation HR 1.62 (95% CI 1.37-1.96, p<0.001) for CG/CC vs GG genotype
Wu H, et al.93 SCN10A AAD-refractory AF, Chinese population Recurrence after RFCA OR 0.36 (95% CI 0.22-0.60, p=7.04x10-5) for rs6795970; other 14 SNPs not significant
Choi EK, et al.91 4q25, 16q22, 1q21 AF without structural heart disease or prior ablation, Korean population Recurrence after RFCA No significant associations
Park JK, et al.92 4q25, 16q22, 1q21 Long-standing persistent AF, Korean population Recurrence after RFCA OR 2.70 (95% CI 1.41-5.14, p=0.003) for rs2106216 of ZFHX3; other SNPs not significant
Wong GR, et al.97 4q25 rs2200733 AF without structural heart disease, Predominantly European cohort Recurrence after RFCA HR 0.35 (95% 0.17-0.73, p=0.005) for arrhythmia-free survival in variant carriers
Shoemaker MB, et al.98 4q25 rs2200733, rs10033464 AF without prior surgical ablation, Vanderbilt AF Registry Any atrial arrhythmia after catheter ablation Survival time ratio 0.76 (95% CI 0.60-0.95, p=0.016) for rs2200733
Husser D, et al.103
4q25 rs2200733, rs10033464
Persistent or AAD-refractory AF, Caucasian population
Early (within 1 week of ablation) and late AF recurrence (within 6 months) after catheter ablation
Early OR 2.08 (95% CI 1.09-3.99, p=0.027) Late OR 2.88 (95% CI 1.25-6.63, p=0.013) rs2200733 also significant
Zhao LQ, et al.99 8 SNPs in 4q25, 16q22 and NAAP, KCNJ5, and IL6R genes Non-lone AF, Chinese population Any atrial arrhythmia >3 months after catheter ablation HR 1.77 (95% CI 1.06-2.94, p=0.028) for homozygous rs2200733
Ulus T, et al.101 11 SNPs in PITX2, ZFHX3, EPHX2, CAV1, TBX5, TGF-1, and SCN10A AF without severe structural heart disease, Turkish population Any atrial arrhythmia after cryoballoon ablation OR 4.50 (95% CI 1.04-19.31, p=0.043) for rs3807989_G in CAV1