Wu G, et al.89
|
IL6R
|
AAD-refractory AF, Chinese population
|
Early (within 1 month) and late (within 1 year) recurrence after
catheter ablation
|
Early: OR 1.84 (95% CI 1.31-2.59, p=4.10x10-4)
Late: OR 1.92 (95% CI 1.30-2.81, p=0.001)
|
Cao H, et al.90
|
RANKL |
Lone AF, Chinese
population |
Recurrence after first-time catheter ablation |
HR 1.62
(95% CI 1.37-1.96, p<0.001) for CG/CC vs GG
genotype |
Wu H, et al.93
|
SCN10A |
AAD-refractory AF,
Chinese population |
Recurrence after RFCA |
OR 0.36 (95% CI 0.22-0.60,
p=7.04x10-5) for rs6795970; other 14 SNPs not
significant |
Choi EK, et al.91
|
4q25, 16q22, 1q21 |
AF without
structural heart disease or prior ablation, Korean population |
Recurrence after RFCA |
No significant associations |
Park JK, et al.92
|
4q25, 16q22, 1q21 |
Long-standing
persistent AF, Korean population |
Recurrence after RFCA |
OR 2.70 (95%
CI 1.41-5.14, p=0.003) for rs2106216 of ZFHX3; other SNPs not
significant |
Wong GR, et al.97
|
4q25 rs2200733 |
AF without
structural heart disease, Predominantly European cohort |
Recurrence
after RFCA |
HR 0.35 (95% 0.17-0.73, p=0.005) for arrhythmia-free
survival in variant carriers |
Shoemaker MB, et al.98
|
4q25 rs2200733, rs10033464 |
AF without prior surgical ablation, Vanderbilt AF Registry |
Any atrial
arrhythmia after catheter ablation |
Survival time ratio 0.76 (95% CI
0.60-0.95, p=0.016) for rs2200733 |
Husser D, et al.103
|
4q25 rs2200733, rs10033464
|
Persistent or AAD-refractory AF, Caucasian population
|
Early (within 1 week of ablation) and late AF recurrence (within 6
months) after catheter ablation
|
Early OR 2.08 (95% CI 1.09-3.99, p=0.027)
Late OR 2.88 (95% CI 1.25-6.63, p=0.013)
rs2200733 also significant
|
Zhao LQ, et al.99
|
8 SNPs in 4q25, 16q22 and NAAP,
KCNJ5, and IL6R genes |
Non-lone AF, Chinese population |
Any atrial
arrhythmia >3 months after catheter ablation |
HR 1.77
(95% CI 1.06-2.94, p=0.028) for homozygous rs2200733 |
Ulus T, et al.101
|
11 SNPs in PITX2, ZFHX3,
EPHX2, CAV1, TBX5, TGF-1, and SCN10A
|
AF without severe structural
heart disease, Turkish population |
Any atrial arrhythmia after
cryoballoon ablation |
OR 4.50 (95% CI 1.04-19.31, p=0.043) for
rs3807989_G in CAV1
|