Recommendations for Genetic Testing
Genetic testing in AF carries multiple potential benefits, including early identification of patients who are at high risk for developing an associated cardiomyopathy and in whom intensified surveillance may be warranted.82 Based on the current available data, we suggest consideration of genetic testing in selected subsets of the AF population (Figure 2):
  1. Patients with lone AF, defined as <66 years of age at time of AF diagnosis and in the absence of structural heart disease
  2. Patients without clinical risk factors for AF, such as hypertension, chronic kidney disease, or diabetes
  3. Patients with AF and family history of ICD implantation
  4. Patients with AF and family history of sudden cardiac death
  5. Patients with AF and who have multigenerational family history of AF83