Histological assessment of inflammation
Assessment of inflammation was performed as described by [22]. In brief, colonic sections were H&E-stained and assessed for disease severity by trained personnel blinded to treatment and genotype. Scoring was based on two parameters; inflammatory cell infiltrate (0-3) and intestinal architecture (0-3). The combined values were added to give a histological score between 0 and 6. Images were acquired using an inverted Nikon Eclipse Ti microscope.