Conclusions:
To our knowledge, this is the first study to look into the association between DS in mothers and obstetric outcomes. In conclusion, our study showed that pregnant women with DS have higher risk to of having preterm delivery and IUFD. In addition, infants born to mothers with are more likely to be SGA and to have congenital anomalies. Women with DS should be counseled preconceptionally and prenatally about their increased risk of premature delivery and adverse neonatal outcomes. Intervention such as screening for and enrolling in drug or smoking cessation programs might be beneficial in eliminating some but not all of these adverse outcomes.