Oxidative stress and autoantibody
Some studies have shown enhancement of autoantibody titers because of oxidative stress in the peritoneal fluid of endometriosis patients. Evidence suggested the presence of oxidative stress in the peritoneal cavity, and markers of increased lipid peroxidation, e.g., antibodies to the oxidized low-density lipoproteins, have been proposed to be increased in the endometriosis’ patients(15). Evidence suggests the enhancement of titers of autoantibodies in women with endometriosis which results in an increase in serum autoantibody titers to oxidatively modified low-density lipoproteins(16). Oxidative stress products, such as lipid peroxides, can be generated from activated macrophages in the peritoneal cavity. Oxidized LDL and the peritoneal fluid of endometriosis patients can be involved in MCP-1 production by endometrial cells and peritoneal mesothelial cells. Accordingly, the growth of ectopic endometrium can be the result of the pre-oxidant environment in the peritoneal fluid and activated macrophages(17).