Oxidative stress and VEGF
Some studies have reported endometriosis as an angiogenesis-dependent disease. Vascular endothelial growth factor (VEGF) as a mitogen has a crucial role in promoting angiogenesis in physiological and pathological conditions(8). In the endometrium, oxidative stress can enhance VEGF production, which by itself can promote the growth of endometrial implants and stimulate angiogenesis. Glycodelin has a crucial role in this process. Expression of glycodelin can be stimulated by oxidative stress, and it can enhance the expression of VEGF in the ectopic endometrial tissue(15).