Oxidative stress and VEGF
Some studies have reported endometriosis as an angiogenesis-dependent
disease. Vascular endothelial growth factor (VEGF) as a mitogen has a
crucial role in promoting angiogenesis in physiological and pathological
conditions(8). In the endometrium, oxidative stress can enhance VEGF
production, which by itself can promote the growth of endometrial
implants and stimulate angiogenesis. Glycodelin has a crucial role in
this process. Expression of glycodelin can be stimulated by oxidative
stress, and it can enhance the expression of VEGF in the ectopic
endometrial tissue(15).