Oxidative stress and autoantibody
Some studies have shown enhancement of autoantibody titers because of
oxidative stress in the peritoneal fluid of endometriosis patients.
Evidence suggested the presence of oxidative stress in the peritoneal
cavity, and markers of increased lipid peroxidation, e.g., antibodies to
the oxidized low-density lipoproteins, have been proposed to be
increased in the endometriosis’ patients(15). Evidence suggests the
enhancement of titers of autoantibodies in women with endometriosis
which results in an increase in serum autoantibody titers to oxidatively
modified low-density lipoproteins(16). Oxidative stress products, such
as lipid peroxides, can be generated from activated macrophages in the
peritoneal cavity. Oxidized LDL and the peritoneal fluid of
endometriosis patients can be involved in MCP-1 production by
endometrial cells and peritoneal mesothelial cells. Accordingly, the
growth of ectopic endometrium can be the result of the pre-oxidant
environment in the peritoneal fluid and activated macrophages(17).