Oxidative stress and infertility
Infertile women with endometriosis have some macrophages that had more inflammatory mediators and iNOS activity. These features of this kind of macrophages can have some roles in infertility related to endometriosis(31). These kinds of macrophages can produce high levels of NO, which can have some deleterious effects on fertility in different ways. A study shows that changes in peritoneal fluid might influence all these reproduction steps(21, 45, 46). According to the deleterious effects of high levels of NO, fertility of women with endometriosis can be improved by either blocking NO effects or reducing the peritoneal fluid NO production(31).