Conclusion
It has been reported that in the peritoneal fluid of endometriosis’ patients, there are activated macrophages and growth factors and high concentrations of cytokines. These conditions have been toxic to embryo survival and sperm function. ROS can mediate these conditions. Moreover, it can have some relations with iron concentrations in peritoneal fluid. Novel therapeutic strategies must regulate intracellular ROS signaling to inhibit the adverse effects of ROS-induced endometriosis-promoting events. According to features of antioxidants, they may inhibit early events of the development of endometriosis.