Oxidative stress and transcription factor
Intercellular ROS in the peritoneal activated macrophages can be
generated due to proinflammatory molecules such as heme and iron. As a
result of this phenomenon, transcription factors such as activator
protein-1 (AP-1), CCAAT/enhancer-binding protein (C/EBP), signal
transducer, and activator of transcription (STAT), hypoxia-inducible
factor-1 (HIF-1), and CCAAT/enhancer-binding protein (C/EBP), and
nuclear factor kappa B (NF-kB) but not HNF can be activated. The
transcription factor NF-kB activates proliferative, antiapoptotic,
chemokines, growth and angiogenic factors, proinflammatory, adhesion
molecules (such as VCAM-1, ICAM-1, and selectin E), and induction
enzymes (iNOS and COX-2) genes in many cell types(13, 14). Agents that
are induced in endometriosis by NF-kB and their function is shown in the
table I.