Oxidative stress and transcription factor
Intercellular ROS in the peritoneal activated macrophages can be generated due to proinflammatory molecules such as heme and iron. As a result of this phenomenon, transcription factors such as activator protein-1 (AP-1), CCAAT/enhancer-binding protein (C/EBP), signal transducer, and activator of transcription (STAT), hypoxia-inducible factor-1 (HIF-1), and CCAAT/enhancer-binding protein (C/EBP), and nuclear factor kappa B (NF-kB) but not HNF can be activated. The transcription factor NF-kB activates proliferative, antiapoptotic, chemokines, growth and angiogenic factors, proinflammatory, adhesion molecules (such as VCAM-1, ICAM-1, and selectin E), and induction enzymes (iNOS and COX-2) genes in many cell types(13, 14). Agents that are induced in endometriosis by NF-kB and their function is shown in the table I.