Oxidative stress and infertility
Infertile women with endometriosis have some macrophages that had more
inflammatory mediators and iNOS activity. These features of this kind of
macrophages can have some roles in infertility related to
endometriosis(31). These kinds of macrophages can produce high levels of
NO, which can have some deleterious effects on fertility in different
ways. A study shows that changes in peritoneal fluid might influence all
these reproduction steps(21, 45, 46). According to the deleterious
effects of high levels of NO, fertility of women with endometriosis can
be improved by either blocking NO effects or reducing the peritoneal
fluid NO production(31).