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Telomerase as a possible key to bypass reproductive cost
  • Radmila Capkova Frydrychova
Radmila Capkova Frydrychova
Biology Centre Czech Academy of Sciences

Corresponding Author:[email protected]

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Telomerase activity and telomere maintenance in certain somatic cells of human adults support the proliferative capacity of these cells and thus contribute to their regenerative potential, and telomerase activity and telomere length are commonly considered lifespan predictors. Eusocial insects provide excellent models for aging research based on their extraordinary caste-related lifespan differences that contradict the typical mammalian fecundity/lifespan trade-off. Telomerase activity is upregulated in the reproductive, long-lived individuals of eusocial insects such as queens and kings, and telomerase activity may act as a key factor in their extended longevity. But, as documented by the presence of telomerase in somatic tissues of numerous invertebrate and vertebrate species, the connection between telomerase activity and the predicted lifespan is not clear. Here, I ask whether somatic telomerase activity in eusocial reproductives may serve its non-canonical function to protect its individuals against the metabolic stress due to reproduction and reflect a more common phenomenon among species. Here, I propose a hypothesis that the presence of telomerase activity in somatic cells reflects a different reproduction strategy of species.
10 Nov 2022Review(s) Completed, Editorial Evaluation Pending
10 Nov 2022Submitted to Molecular Ecology
22 Nov 2022Reviewer(s) Assigned
06 Jan 2023Editorial Decision: Revise Minor
26 Jan 2023Review(s) Completed, Editorial Evaluation Pending
26 Jan 20231st Revision Received
30 Jan 2023Editorial Decision: Accept