References:
1. Wu Z, McGoogan JM. Characteristics of and Important Lessons From the
Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a
Report of 72 314 Cases From the Chinese Center for Disease Control and
Prevention. JAMA 2020;323:1239-1242.
2. Ssentongo P, Ssentongo AE, Heilbrunn ES, Ba DM, Chinchilli VM.
Association of cardiovascular disease and 10 other pre-existing
comorbidities with COVID-19 mortality: A systematic review and
meta-analysis. PLoS One 2020;15.
3. Fan G, Tu C, Zhou F, et al. Comparison of severity scores for
COVID-19 patients with pneumonia: a retrospective study. Eur Respir J
2020;56.
4. Wendel Garcia PD, Fumeaux T, Guerci P, et al. Prognostic factors
associated with mortality risk and disease progression in 639 critically
ill patients with COVID-19 in Europe: Initial report of the
international RISC-19-ICU prospective observational cohort.
EClinicalMedicine 2020;25:100449.
5. Siddiqi HK, Mehra MR. COVID-19 illness in native and immunosuppressed
states: A clinical–therapeutic staging proposal. The Journal of Heart
and Lung Transplantation 2020;39:405-407.
6. Rao SN, Manissero D, Steele VR, Pareja J. A Narrative Systematic
Review of the Clinical Utility of Cycle Threshold Values in the Context
of COVID-19. Infect Dis Ther July 2020:1-14.
7. Magleby R, Westblade LF, Trzebucki A, et al. Impact of SARS-CoV-2
Viral Load on Risk of Intubation and Mortality Among Hospitalized
Patients with Coronavirus Disease 2019. Clinical Infectious Diseases: An
Official Publication of the Infectious Diseases Society of America June
2020.
8. Salvatore PP, Dawson P, Wadhwa A, et al. Epidemiological Correlates
of PCR Cycle Threshold Values in the Detection of SARS-CoV-2. Clin
Infect Dis September 2020.
9. Westblade LF, Brar G, Pinheiro LC, et al. SARS-CoV-2 Viral Load
Predicts Mortality in Patients with and without Cancer Who Are
Hospitalized with COVID-19. Cancer Cell September 2020.
10. Pujadas E, Chaudhry F, McBride R, et al. SARS-CoV-2 viral load
predicts COVID-19 mortality. The Lancet Respiratory Medicine 2020;8:e70.
11. Faíco-Filho KS, Passarelli VC, Bellei N. Is Higher Viral Load in
SARS-CoV-2 Associated with Death? The American Journal of Tropical
Medicine and Hygiene September 2020.
12. Shlomai A, Ben-Zvi H, Glusman Bendersky A, Shafran N, Goldberg E,
Sklan EH. Nasopharyngeal viral load predicts hypoxemia and disease
outcome in admitted COVID-19 patients. Critical Care 2020;24:539.
13. Lesho E, Reno L, Newhart D, et al. Temporal, Spatial, and
Epidemiologic Relationships of Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) Gene Cycle Thresholds: A Pragmatic
Ambi-directional Observation. Clin Infect Dis August 2020.
14. Argyropoulos KV, Serrano A, Hu J, et al. Association of Initial
Viral Load in Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) Patients with Outcome and Symptoms. The American Journal of
Pathology 2020;190:1881-1887.
15. Ra SH, Lim JS, Kim G, Kim MJ, Jung J, Kim S-H. Upper respiratory
viral load in asymptomatic individuals and mildly symptomatic patients
with SARS-CoV-2 infection. Thorax August 2020.
16. Asai N, Sakanashi D, Ohashi W, et al. Could threshold cycle value
correctly reflect the severity of novel coronavirus disease 2019
(COVID-19)? J Infect Chemother 2021;27:117-119.
17. Han A, Czajkowski LM, Donaldson A, et al. A Dose-finding Study of a
Wild-type Influenza A(H3N2) Virus in a Healthy Volunteer Human Challenge
Model. Clin Infect Dis 2019;69:2082-2090.
18. Chu C-M, Poon LLM, Cheng VCC, et al. Initial viral load and the
outcomes of SARS. CMAJ 2004;171:1349-1352.
19. Shi F, Wu T, Zhu X, et al. Association of viral load with serum
biomakers among COVID-19 cases. Virology 2020;546:122-126.
20. Chen X, Zhao B, Qu Y, et al. Detectable serum SARS-CoV-2 viral load
(RNAaemia) is closely correlated with drastically elevated interleukin 6
(IL-6) level in critically ill COVID-19 patients. Clin Infect Dis April
2020.
21. Cerutti F, Burdino E, Milia MG, et al. Urgent need of rapid tests
for SARS CoV-2 antigen detection: Evaluation of the SD-Biosensor antigen
test for SARS-CoV-2. J Clin Virol 2020;132:104654.
22. Corman VM, Landt O, Kaiser M, et al. Detection of 2019 novel
coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill 2020;25.
23. Binnicker MJ. Can the SARS-CoV-2 PCR Cycle Threshold Value and Time
from Symptom Onset to Testing Predict Infectivity? Clinical Infectious
Diseases: An Official Publication of the Infectious Diseases Society of
America June 2020.
24. Singanayagam A, Patel M, Charlett A, et al. Duration of
infectiousness and correlation with RT-PCR cycle threshold values in
cases of COVID-19, England, January to May 2020. Euro Surveill 2020;25.
25. Van Damme W, Dahake R, van de Pas R, Vanham G, Assefa Y. COVID-19:
Does the infectious inoculum dose-response relationship contribute to
understanding heterogeneity in disease severity and transmission
dynamics? Med Hypotheses November 2020.
26. Arons MM, Hatfield KM, Reddy SC, et al. Presymptomatic SARS-CoV-2
Infections and Transmission in a Skilled Nursing Facility. N Engl J Med
April 2020.
27. He X, Lau EHY, Wu P, et al. Temporal dynamics in viral shedding and
transmissibility of COVID-19. Nat Med 2020;26:672-675.
28. Kimball A, Hatfield KM, Arons M, et al. Asymptomatic and
Presymptomatic SARS-CoV-2 Infections in Residents of a Long-Term Care
Skilled Nursing Facility - King County, Washington, March 2020. MMWR
Morb Mortal Wkly Rep 2020;69:377-381.
29. To KK-W, Tsang OT-Y, Leung W-S, et al. Temporal profiles of viral
load in posterior oropharyngeal saliva samples and serum antibody
responses during infection by SARS-CoV-2: an observational cohort study.
Lancet Infect Dis 2020;20:565-574.
30. Zou L, Ruan F, Huang M, et al. SARS-CoV-2 Viral Load in Upper
Respiratory Specimens of Infected Patients. N Engl J Med
2020;382:1177-1179.
31. Jacot D, Greub G, Jaton K, Opota O. Viral load of SARS-CoV-2 across
patients and compared to other respiratory viruses. Microbes Infect
September 2020.
32. Karahasan Yagci A, Sarinoglu RC, Bilgin H, et al. Relationship of
the cycle threshold values of SARS-CoV-2 polymerase chain reaction and
total severity score of computerized tomography in patients with COVID
19. Int J Infect Dis 2020;101:160-166.
33. Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC.
Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus
Disease 2019 (COVID-19): A Review. JAMA 2020;324:782-793.
34. Nakagawara K, Masaki K, Uwamino Y, et al. Acute onset
olfactory/taste disorders are associated with a high viral burden in
mild or asymptomatic SARS-CoV-2 infections. International Journal of
Infectious Diseases 2020;99:19.
35. Cho RH, To ZW, Yeung ZW, et al. COVID‐19 Viral Load in the Severity
of and Recovery from Olfactory and Gustatory Dysfunction. The
Laryngoscope.
36. Lv H, Zhang W, Zhu Z, et al. Prevalence and recovery time of
olfactory and gustatory dysfunction in hospitalized patients with
COVID‑19 in Wuhan, China. Int J Infect Dis 2020;100:507-512.
37. Saponaro F, Rutigliano G, Sestito S, et al. ACE2 in the Era of
SARS-CoV-2: Controversies and Novel Perspectives. Front Mol Biosci
2020;7.
38. Yao Y, Wang H, Liu Z. Expression of ACE2 in airways: Implication for
COVID-19 risk and disease management in patients with chronic
inflammatory respiratory diseases. Clin Exp Allergy September 2020.
39. Han MS, Byun J-H, Cho Y, Rim JH. RT-PCR for SARS-CoV-2: quantitative
versus qualitative. The Lancet Infectious Diseases 2020;0.