Activators PAR1 PAR2 PAR3 PAR4 Reference
Serine proteases
Thrombin, cathepsin G
trypsin, tryptase, cathepsin S
Thrombin
Thrombin, cathepsin G
1, 2, 3, 59
Urinary proteases Urokinase Kallikrein-2,4,5,6 kallikrein-14 2, 22, 60, 61
Coagulation proteases
FXa, APC, TF-VIIa, Plasmin
FXa, TF-VIIa, APC
FXa, APC
FXa, TFVIIa, Plasmin
3, 59,60
Synthetic peptides TRAP-6,TFLLR-NH2 SLIGKV-NH2, SGLGL-NH2 AYPGKF-NH2 2, 23